双氯芬酸钠栓在骨性关节炎患者初次单侧全膝关节置换术围术期镇痛的应用被引量：7

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摘要目的研究双氯芬酸钠栓经直肠给药在骨性关节炎患者初次单侧全膝关节置换术(TKA)围术期镇痛的疗效及安全性。方法回顾性分析福建中医药大学附属厦门市中医院骨三科收治的因骨性关节炎行单侧TKA病例22例,分为治疗组1(塞来昔布胶囊+静脉镇痛泵)和治疗组2(塞来昔布胶囊+静脉镇痛泵+双氯芬酸钠栓),分别记录两组患者手术前后的VAS评分及膝关节活动度。结果两组基线VAS评分及膝关节主、被动屈伸活动度比较,差异均无统计学意义(P>0.05);术后7d两组VAS评分及膝关节主、被动屈伸活动度比较,差异均有统计学意义(P<0.05);术后14d两组VAS评分及膝关节主、被动屈伸活动度比较,差异均有统计学意义(P<0.05)。结论骨性关节炎患者初次单侧TKA围术期应用双氯芬酸钠栓经直肠给药能显著减轻患者术后疼痛,并提高术后膝关节活动度;塞来昔布胶囊+静脉镇痛泵+双氯芬酸钠栓的镇痛模式安全有效。

作者周毅强张建新周殿阁林蔚莘许恺林国文陈志斌

机构地区福建中医药大学附属厦门市中医院骨三科北京大学人民医院骨科

出处《重庆医学》 CAS 北大核心 2015年第31期4418-4420,共3页 Chongqing medicine

关键词二氯芬酸钠剂骨关节炎关节成形术置换膝围手术期镇痛

分类号 R687.4 [医药卫生—骨科学]

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