摘要
目的:对舒血宁注射液、丹红注射液、丹参酮ⅡA磺酸钠注射液3种药物治疗冠心病不稳定性心绞痛的临床疗效进行分析比对研究,在常规治疗剂量下选择出副作用小、临床疗效较为显著的药物,为临床治疗冠心病不稳定性心绞痛的药物选择提供临床依据。方法:将90例冠心病不稳定性心绞痛患者分为舒血宁注射液组、丹红注射液组、丹参酮ⅡA磺酸钠注射液各30例,以上90例患者均常规口服治疗冠心病不稳定性心绞痛的基础药物。3组药物输液方法每日1次,疗程2周,疗程结束后比较3组患者冠心病不稳定性心绞痛临床症状改善情况和心电图变化及C反应蛋白的变化情况。结果:2周疗程结束后舒血宁注射液组的不稳定性心绞痛临床症状改善率66.67%,丹红注射液组的不稳定性心绞痛临床症状改善率80%,丹参酮ⅡA磺酸钠注射液组的不稳定性心绞痛临床症状改善率70%,丹红注射液组在改善冠心病不稳定型心绞痛的症状与舒血宁注射液组和丹参酮ⅡA磺酸钠注射液组比较差异有统计学意义,舒血宁注射液组和丹参酮ⅡA磺酸钠注射液组2组在改善冠心病不稳定性心绞痛临床症状方面比较差异无统计学意义;丹红注射液组(66.67%)在改善心电图总有效率方面与舒血宁注射液组(50%)和丹参酮ⅡA磺酸钠注射液组(53.33%)比较差异有统计学意义,舒血宁注射液组与丹参酮ⅡA磺酸钠注射液组比较差异无统计学意义);3个治疗组治疗后与治疗前比较差异有统计学意义,3个治疗组治疗后比较差异无统计学意义。结论:丹红注射液治疗冠心病不稳定性心绞痛的疗效优于舒血宁注射液和丹参酮ⅡA磺酸钠注射液,能使患者在治疗中受益最大,值得在临床中推广应用。
Objective： To comparative analyze the shu ning blood injection,Dan hong injection,tanshinone Ⅱ A sulfonic acid sodium injection on treating the coronary heart disease（ CHD） unstable angina. In the conventional treatment,to choose the drays with little side effects and clinical efficacy. Choose for drugs in the clinical treatment of coronary heart disease unstable angina to provide clinical basis. Methods： Devided 90 cases of coronary heart disease unstable angina patients into three groups,shuxuening injection group and control group,30 cases blood Dan hong injection group of 30 cases,tanshinone Ⅱ A sulfonic acid sodium injection 30 cases,More than 90 patients have regular oral basic drugs for the treatment of coronary heart disease unstable angina. 3 groups for once-daily treatment drug infusion method,treatment course 2 weeks,after the treatment compared three groups of patients with coronary heart disease unstable angina improve clinical symptoms and electrocardiogram（ ECG） changes,and the change of c-reactive protein. Results： After 1. 2weeks treatment shuxue ning injection group blood period for unstable angina symptoms（ 66. 67%）,Dan hong injection group period for unstable angina symptoms（ 80%）,tanshinone Ⅱ A sulfonic acid sodium injection group period for unstable angina symptoms（ 70%）,Dan hong injection group in improving symptoms of coronary heart disease unstable angina and Shuxuening injection group and tanshinone Ⅱ A sulfonic acid sodium injection group have significant difference,Shuxuening injection group and tanshinone Ⅱ A sulfonic acid sodium injection group in improving the clinical symptoms of coronary heart disease unstable angina has no significant difference. While Dan Hong injection group（ 66. 67%） in improving the electrocardiogram（ ECG） with Shuxuening injection group total effective rate（ 50%） and tanshinone Ⅱ A sulfonic acid sodium injection group（ 53. 33%） has significant difference. Shuxue ning injection group blood and tanshinone Ⅱ A sulfonic acid sodium injection group has no significant difference. Three treatment group after treatment compared with before treatment had significant difference,the comparison between three treatment group after treatment has no significant difference. Conclusion： Dan hong injection in the treatment of coronary heart disease unstable angina curative effect is better than that of Shuxuening injection and tanshinone Ⅱ A sulfonic acid sodium injection,can make the patients in the treatment of benefit maximum. It is worthy for further popularization and application in clinical.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2015年第10期1268-1270,1274,共4页
JOURNAL OF BASIC CHINESE MEDICINE
关键词
舒血宁注射液
丹红注射液
丹参酮ⅡA磺酸钠注射液
冠心病不稳定性心绞痛
临床疗效分析
Shuxuening injection
Danhong injection
Tanshinone Ⅱ A sulfonic acid sodium injection
Coronary heart disease unstable angina
Clinical curative effect analysis
