摘要
目的观察奥氮平联合艾司西酞普兰在脑外伤所致精神障碍伴抑郁症状治疗中的疗效和安全性。方法对脑外伤所致精神障碍伴抑郁症状的58例患者使用奥氮平,奥氮平起始剂量5 mg/天,4周内视病情调整至（5～20 mg/天）。联合艾司西酞普兰,艾司西酞普兰每日起始剂量5 mg/天,按病情逐渐增量至（10～20 mg/天）治疗,观察其疗效和不良反应。结果完成治疗及评定患者58例,奥氮平治疗2、4、6周后,BPRs评分均较治疗前下降（P〈0.05）,总有效率93.1%。患者焦虑抑郁改善显著,副反应少,仅7例出现体重增加、嗜睡、头昏等副反应。结论在脑外伤所致精神障碍伴抑郁症状的治疗中,用奥氮平联合艾司西酞普兰改善精神行为障碍起效快,疗效好,安全,无明显药物间相互不良反应。
Objective To observe the olanzapine combined escitalopram citalopram in brain injury caused by mental disorders associated with efficacy and safety in the treatment of depressive symptoms. Methods The mental disorders caused by traumatic brain injury patients with depressive symptoms of 58 cases with use of olanzapine,olanzapine starting dose of 5 mg / day,four weeks depending on the condition to adjust（ 5 ～ 20 mg / day）. Joint escitalopram citalopram,escitalopram citalopram daily starting dose of 5 mg / day,according to the condition gradually increase to（ 10 ～ 20 mg / day）treatment,the curative effect and adverse reaction was observed. Results 58 patients with complete treatment and evaluation,olanzapine 2,4,6 weeks after treatment,was falling the BPRs score（ P〈0. 05）,the total effective rate was93. 1%. Patients with anxiety depression improved significantly,less side effects,only 7 cases with weight gain,sleepiness,dizziness and other side effects. Conclusions In brain injury caused by the treatment of mental disorders associated with depressive symptoms,combined with olanzapine escitalopram citalopram improve mental behavior disorder work fast,good curative effect,safety,no obvious between drug adverse reactions to each other.
出处
《航空航天医学杂志》
2015年第10期1193-1194,共2页
Journal of Aerospace medicine
关键词
奥氮平
艾司西酞普兰
脑外伤
精神障碍
olanzapine.Escitalopram citalopram
Brain injury
Mental disorders
