摘要
用高效液相色谱法检测判断α-熊果苷在不同基础环境和不同化妆品基质原料条件下的稳定性、含量变化和氢醌是否产生。实验结果表明：（1）温度对α-熊果苷稳定性影响不大,10℃-60℃的范围里,α-熊果苷的稳定性较好,且均未检出氢醌;（2）在p H=4-8的范围里,α-熊果苷稳定性较好,也未检出氢醌;（3）在日光照射下,α-熊果苷的色谱峰面积不随着光照时间的增加而改变;在紫外光照射下,α-熊果苷的色谱峰面积随紫外照射时间的增加而逐渐减小,但实验结果未发现氢醌生成;（4）α-熊果苷在尼泊金甲酯、脂肪醇聚醚-20、K12-Na、甘油、金属铜离子基础原料的溶液中的稳定性比较好,均未检出氢醌。
With the fast development of whitening cosmetics research, their safety evaluation has attracted more and more attention of consumers and enterprises. In this paper, stability and of α-arbutin and it is probable generating hydroquinone in different basis environments and in different matrix materials of cosmetics were developed. The change of content of α-arbutin and hydroquinone were determined by high performance liquid chromatography. The results showed that：（1） the temperature had little effect on the stability of α-arbutin in the range of 10 ℃ to 60 ℃ and hydroquinone were not detected.（2） In the range of p H4-8, the stability of α-arbutin was also good, and hydroquinone was also not detected.（3） In sunlight, chromatographic peak area of α-arbutin does not increase with illumination time of change while under UV irradiation, peak area of α-arbutin gradually decreases with increasing UV irradiation time;（4） α-arbutin performed good stabilities in the solution of the methyl 4-hydroxybenzoate, fatty alcohol polyether-20, K12-Na,glycerin and metal ions（Cu2＋） respectively and there was no detection of hydroquinone in the solution of α-arbutin.
出处
《浙江化工》
CAS
2015年第10期47-50,共4页
Zhejiang Chemical Industry
基金
浙江省自然科学重点基金(NO:Z14B070002)
关键词
α-熊果苷
化妆品
氢醌
稳定性
alpha-arbutin
cosmetic
hydroquinone
stability
