摘要
目的:探索脑梗死患者中脑白质病变的危险因素。方法:以2012年1月至2014年12月我院神经内科收治的837例脑梗死患者为研究对象,采用Fazekas量表评价核磁共振T2WI脑室旁白质和皮质下白质病变严重程度。分别比较不同程度脑室旁白质病变、皮质下白质病变患者间各个危险因素的差异,采用Logistic回归分析脑白质病变的危险因素。结果:年龄、高血压是脑室旁白质(OR年龄=1.090,95%CI:0.073-0.099,P<0.05;OR高血压=1.699,95%CI:0.242-0.818,P<0.05)和皮质下白质病变(OR年龄=1.074,95%CI:0.059-0.083,P<0.05;OR高血压=1.353,95%CI:0.017-0.588,P<0.05)共同的危险因素。收缩压(OR=1.008,95%CI:0.001-0.015,P<0.05)是皮质下白质病变的危险因素。结论:在脑梗死患者中,年龄、高血压是脑室旁白质病变、皮质下白质病变共同的危险因素,收缩压是皮质下白质病变的危险因素。
Objective： To explore the risk factors of white matter lesion（WML） in patients with ischemic stroke. Methods： 837 consecutive patients with acute ischemic stroke who underwent MRI were enrolled in Neurology Department in PLA General Hospital from January 2012 to December 2014. The severity of periventricular white matter lesion（PWML） and deep white matter lesion（DWML）were evaluated using Fazekas scale. The risk factors were compared among different grades of PWML and DWML respectively. Logistic regression was employed to find risk factors of PWML and DWML. Results： Age and hypertension were associated with the severity of PWML（ORage=1.090, 95%CI： 0.073-0.099, P〈0.05; ORhypertension=1.699, 95%CI： 0.242-0.818, P〈0.05） and DWML（ORage=1.074,95% CI： 0.059-0.083, P〈0.05; ORhypertension=1.353, 95% CI： 0.017-0.588, P〈0.05）. SBP was associated with the severity of DWML（OR=1.008, 95%CI： 0.001-0.015, P〈0.05）. Conclusions： Age and hypertension are risk factors of both PWML and DWML, and SBP is the risk factor of DWML.
出处
《现代生物医学进展》
CAS
2015年第28期5475-5479,5495,共6页
Progress in Modern Biomedicine
基金
首都医学发展科研基金项目(2009-2037)
北京市自然科学基金项目(7123227)
关键词
脑白质病变
核磁共振成像
危险因素
White matter lesion
Magnetic resonance imaging
Risk factors
