摘要
目的探索血糖对急性脑梗死患者预后的影响及与外周血细胞因子的相关性。方法分析2010年1月—2014年12月在义乌市急救中心接受治疗的急性脑梗死患者101例,以入院时即刻血糖(GLU)是否正常分为2组,观察组患者45例(GLU≥7.2 mmol/L),对照组患者56例(GLU<7.2 mmol/L)。结果 2组患者外周血IL-6、IL-10及TGF-β水平比较差异均无统计学意义(P>0.05)。观察组患者外周血TNF-α(t=3.080,P=0.003)、CRP(t=8.835,P<0.001)水平显著高于对照组。观察组患者血糖水平与外周血TNF-α呈现显著正相关,具有统计学意义(r=0.787;P<0.001);观察组患者血糖水平与外周血CRP呈现显著正相关,具有统计学意义(r=0.814;P<0.001)。观察组发病后3个月累积病死率显著高于对照组,相比较差异具有统计学意义(24.44%,11/45 vs.8.93%,5/56;χ2=4.207,P=0.042)。结论急性脑梗死患者血糖升高提示预后不良,且与外周血TNF-α、CRP水平呈现正相关关系。
Objective To analyze the impact of blood glucose on the prognosis of patients with acute cerebral infarction and its correlation with cytokines. Methods The clinical data of patients with acute cerebral infarction in our hospital from 2010 to 2014 was analyzed retrospectively. The patients were divided into two groups by admission blood glucose level （ GLU ） ,45 cases of observation group patients （ GLU ≥ 7.2 mmol/L）, 56 cases of control group patients （ GLU 〈 7.2 mmol/L）. Results The levels of GLU in Group Awas higher when compared with Group B, there was significant difference between the two groups （ t = 12. 380 ,P 〈 0. 001 ）. The levels of CRP and TNF-α in Group A were higher than these of Group B, the difference was statistically significant （P 〈 0. 001 ）. The correlation analysis showed that GLU level was positively correlated with the levels of CRP and TNF-α（ P 〈 0.001 ）. The cumulative mortality 3 months after the onset of disease in Group A was higher than that in Group B, the difference was statistical （ X2 = 4. 207, P = 0. 042 ）. Conclusion The elevatedlevels of GLU may indicate a bad prognosis in patients with acute cerebral infarction.
出处
《中华全科医学》
2015年第11期1799-1801,共3页
Chinese Journal of General Practice
关键词
急性脑梗死
血糖
细胞因子
预后
Acute cerebral infarction
Blood glucose
Cytokines
Prognosis
