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喉癌患者凝血、纤溶指标及血小板参数与术后复发的关系研究 被引量:3

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摘要 目的分析凝血、纤溶指标及血小板参数在喉癌患者中的表达水平,探讨凝血、纤溶系统与喉癌复发的关系。方法收集105例有完整病例资料及回访结果的喉癌患者,同期住院的60例喉部良性疾病患者,比较入院后次日晨起检测的凝血五项及血常规结果,分析凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(Fib)、D-二聚体(D-dimer),以及血小板计数(PLT)、血小板压积(PCT)、血小板分布宽度(PDW)、血小板分布体积(MPV)等指标的差异,探讨各项指标与喉癌术后复发的关系。结果 Fib、D-二聚体检测值在喉癌患者中明显高于对照组(P<0.05)。Fib、D-二聚体、PLT在Ⅲ、Ⅳ期喉癌患者中明显高于Ⅰ、Ⅱ期(P<0.05)。APTT在转移组中明显缩短于未转移组,Fib、D-二聚体、PLT在转移组中明显高于未转移组(P<0.05)。Fib、D-二聚体、PLT在喉癌复发组中明显高于未复发组差异均有统计学意义(P<0.05)。结论喉癌患者血液呈高凝状态,且存在继发纤溶亢进和血小板计数增多,这种改变与喉癌术后复发密切相关。
出处 《河北医药》 CAS 2015年第21期3271-3273,共3页 Hebei Medical Journal
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