摘要
目的观察亚临床甲状腺疾病孕妇的心血管疾病相关因子情况。方法本文为前瞻病例对照研究。研究对象来自2012年7月1日至2013年6月30日在苏州太仓市城乡4家医疗机构及社区建档进行系统检查且在本地分娩的1540例单胎初产孕妇,使用罗氏电化学发光自设的早孕期促甲状腺激素（TSH）及游离甲状腺素（FT4）特异性区间筛选,亚临床甲状腺功能亢进（L-TSH）80例,亚临床甲状腺功能减退（H-TSH）48例,选择同期筛查的160例为对照组（N-TSH）,分别于早孕（6-12＋6周）及晚孕期（28-28＋6周）观察其体重、血压、血脂和血糖,并进行比较分析。结果 L-TSH 80例（8.1%,80/1540）,H-TSH 48例（3.1%,48/1540）,早孕期及晚孕期,三组的总胆固醇（TC）及低密度脂蛋白（LDL-C）均有统计学意义（P〈0.01）,H-TSH早孕期TC较对照组为低,而L-TH早孕期较之为高,晚孕期两组间已无明显差异。晚孕期三组的体重、体重增幅、收缩压和舒张压有统计学意义（P〈0.05）,L-TSH体重增幅低于对照组,H-TSH体重增幅高于对照组;晚孕期H-TSH和L-TSH两组收缩压、舒张压均高于对照组,以H-TSH为明显;早孕期收缩压和舒张压无统计学意义。结论使用妊娠期甲状腺功能指标的特异性区间进行筛查是判断亚临床甲状腺疾病的重要工作基础,这一疾病对孕期血脂、血压、体重增长有不良的促进作用。
Objective To elaborate the change about risk factors of cardiovascular disease in the early and late pregnancy with subclinical thyroid diseases. Methods Perspective study was used in this article. A total of 1540 cases of single births primiparas were chosen, filed from July 1st, 2012 to June 30 th, 2013 in the 4 hospitals or communities of Taicang. Specific interval of Thyrotrophin（TSH） and free thyroxine 4（FT4） derived from electrochemical luminescence of ROCHE were used to screen.Forty-eight cases of subclinical hyperthyroidism（L-TSH）, 80 cases of subclinical hypothyroidism（H-TSH） and 160 controls（NTSH） were observed in the early（6-12＋6week） and late（28-28＋6week） pregnancy. The index included blood sugar, cholesterol（TG）, triglyceride（TC）, high-density lipoprotein（HDL-C）, low-density lipoprotein（LDL-C）, blood pressure and weight. Results（1）There were statistical significance of TG and LCL-C in the early and late pregnancy（P〈0.01）. In the early, TC of H-TSH group was lower than that in the control group, and TC of L-TH group was higher than that in the control group. In late pregnancy, TC had no significant difference between H-TSH group and L-TH group.（2） Weight gain of L-TSH group was lower than that in the control group. Weight gain of H-TSH group was higher than that in the control group. In late pregnancy, systolic pressure and diastolic pressure were higher than those in control group. There was no statistical difference of systolic and diastolic blood pressure in the early pregnancy. Conclusion These data provide an important basis for the diagnosis of the subclinical thyroid disease in pregnant women by using the specific interval of TSH and FT4, the subclinical thyroid disease had a bad role in promoting TG,LDL-C, weight and blood pressure during the pregnancy.
出处
《实验与检验医学》
CAS
2015年第5期560-562,共3页
Experimental and Laboratory Medicine
基金
国家自然科学基金资助项目(编号:81370084)
太仓市科技支撑计划-社会发展项目(编号:TS1246)
关键词
妊娠
妊娠期亚临床甲状腺疾病
心血管病风险因子
Pregnancy
Subclinical thyroid disease in pregnancy
Cardiovascular risk factors
