摘要
目的探讨血清中补体B因子及免疫球蛋白Ig A、Ig G、Ig M含量的检测在强直性脊柱炎(AS)诊疗中的应用价值。方法在全自动特定蛋白分析仪上采用免疫速率散射比浊法测定AS患者组及健康对照组血清中补体B因子(CFB)及免疫球蛋白Ig A、Ig G、Ig M含量,流式细胞术分析两组人群HLA-B27表达情况,进一步分析指标间的关系。结果 AS患者组HLA-B27阳性率极高,且血清中CFB、Ig A和Ig G含量均增高,与对照组相比差异有统计学意义(P<0.01),AS患者血清CFB升高与免疫球蛋白升高无明显相关性(P>0.05),而Ig A和Ig G含量升高有一定程度相关性(P<0.05)。结论血清中CFB及免疫球蛋白Ig A、Ig G、Ig M含量的检测对AS的临床诊断和治疗提供重要的依据。
Objective To detect the serum levels of complement factor B and immunoglobulins in patients with ankylosing spondyli -tis （ AS） , and analyze application value in the diagnosis and treatment of AS .Methods Immune rate nephelometry was used to detect complement factor B and immunoglobulins on Immage ？ 800 Rate Nephelometer （Beckman Coulter Inc.Brea, CA, USA）,and HLA-B27 was measured in AS and health controls .Results The positive rate of HLA-B27 was extremely high in AS patients .Serum complement factor B and immunoglobulins（IgA and IgG）in AS patients were significantly higher than those of health controls （P〈0.01）.And the ele-vated concentration of CFB in AS patients had no significant correlation with those of serum immunoglobulins , while there was certainly positive correlation between the increased serum level of IgA and those of IgG .Conclusion Detecting the concentration of CFB and im-munoglobulins（IgA ,IgG and IgM） provides an important basis for clinical diagnosis and treatment of AS .
出处
《医学研究杂志》
2015年第10期135-137,共3页
Journal of Medical Research
