摘要
目的 探讨IL-8、IL-18在种植体周围炎龈沟液（ GCF）中的表达及意义. 方法 选择2011年1月~2013年12月期间40例种植体周围炎患者为研究对象. 另选择健康种植体患者40例. 选择健康人群50例为健康对照组. 统计3组探诊深度（PD）、龈沟出血指数（SBI）、IL-8、IL-18质量浓度,并对GCF中IL-8、IL-18质量浓度与性别、年龄、PD、SBI进行相关性分析. 结果 种植体周围炎组PD、SBI、GCF均高于健康种植体组和对照组,差异有统计学意义（P〈0.01）;但健康种植体组和对照组PD、SBI、GCF差异无统计学意义（P〉0.05）;种植体周围炎组IL-8、IL-18水平高于健康种植体组和对照组,差异有统计学意义（P〈0.01）,健康种植体组IL-8、IL-18水平高于对照组,差异有统计学意义（P〈0.01）;不同性别种植体周围炎患者GCF中IL-8、IL-18水平比较,差异无统计学意义（P〉0.05）;≥60岁组IL-8、IL-18水平高于〈60岁组和对照组,差异有统计学意义（P〈0.01）,〈60岁组IL-8、IL-18水平高于对照组,差异有统计学意义（P〈0.01）;GCF 与PD、SBI、IL-8、IL-18呈正相关（P〈0.05）;IL-8、IL-18与年龄、PD、SBI呈正相关（P〈0.05）;IL-8和IL-18之间呈正相关（P〈0.05）. 结论 IL-8、IL-18在种植体周围炎患者GCF中呈高表达;GCF中IL-8、IL-18的特异性表达与种植体周围炎密切相关.
Objective To study IL -8,IL-18 expression in peri -implantitis gingival crevicular fluid and clinical significance . Methods Between January 2011 and December 2013, 40 patients with peri-implantitis were selected as the research object .40 cases of healthy implant patients were selected .50 cases of healthy people healthy were selected as the controls .The probing depth （ PD） , sulcus bleeding index （SBI）, GCF IL-8,IL-18 mass concentration in the three groups were tested , and correlation analysis between IL -8,IL-18 mass concentration in GCF and gender , age, PD and SBI were made.Results PD and SBI, GCF in peri-implant group were higher than healthy implant group and the control group , and the difference was statistically significant （P〈0.01）.But the PD and SBI, GCF of healthy implant group and the control group B had no obvious difference （P〉0.05）;IL-8,IL-18 in peri-implant group was higher than healthy implant group and the control group , and the difference was statistically significant （P〈0.01）.IL-8,IL-18 levels in healthy implant group was higher than the control group , and difference was statistically significant （P〈0.01）.Peri-implant patients with different gender in GCF IL -8,IL-18 levels, and there was no statistically significant difference （P〉0.05）.IL-8,IL-18 levels of patients whose ages were 60 or higher in peri-implant group were higher than the 〈60 years old group and the control group ,and the difference was statistically significant （P〈0.01）.IL-8,IL-18 levels in the 〈60 years old group were higher than the control group , and difference was statistically significant （P〈0.01）.The GCF was positively correlated with PD, SBI, IL-8, IL-18 （P〈0.05）. IL-8, IL-18 was positively correlated with age , PD, SBI （P〈0.05）.There was a positive correlation between IL -8 and IL-18 （P〈0.05）.Conclusion IL-8,IL-18 show high expression in GCF in peri -implantitis.The specific expressions of IL -8,IL-18 in GCF are closely related to peri -implantitis.
出处
《医学研究杂志》
2015年第10期155-158,共4页
Journal of Medical Research
关键词
种植体周围炎
龈沟液
细胞因子
炎性反应
免疫功能
Peri - implantitis
Gingival crevicular fluid
Cytokines
Inflammatory reaction
Immune function
