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创伤后应激障碍患者血清吲哚胺2,3-双加氧酶表达变化及意义 被引量：2

Expression changes and significance of serum indoleamine 2,3-dioxygenase in patients with post-traumatic stress disorder
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摘要 目的初步探讨创伤后应激障碍(PTSD)患者血清中干扰素-γ(INF-γ)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)与吲哚胺2,3-双加氧酶(IDO)表达变化及意义。方法收集80例PTSD患者(研究组)与80例正常对照者(对照组),采用酶联免疫吸附法(ELISA)与Western Blot方法对两组血清中INF-γ、TNF-α、IL-6及IDO进行检测并比较。结果研究组血清INF-γ、TNF-α、IL-6及IDO均高于对照组(P<0.05)。结论 PTSD患者存在显著的免疫功能紊乱,INF-γ、TNF-α、IL-6及IDO可能在PTSD的发病机理中起着重要作用。 Objective To explore the expression change and significance of serum interferon-γ（ INF-γ） , tumor necrosis factor （TNF-α）, interleukin-6 （IL-6） and indoleamine 2,3-dioxy-genase （IDO） in patients with post-traumatic stress disorder （PTSD）.Methods 80PTSDpatients（studygroup）and80healthycontrols（controlgroup）wereassessedwithenzyme-linked immunosorbent assay （ ELISA） and Western Blot to detect and compare the serum levels of INF-γ, TNF-α, IL-6 and IDO. Results Serum levels of INF-γ, TNF-α, IL-6 and IDO in study group were significantly higher than those in control group （ P〈0.05）.Conclusion Noticeable immune dysfunctions may exist in PTSD patients.INF-γ, TNF-α, IL-6 and IDO may play an important role in the pathogenesis of PTSD.
作者 何主强 殷莉 黄姗姗
机构地区 武汉市第一医院 华中科技大学同济医学院附属同济医院
出处 《精神医学杂志》 2015年第5期345-347,共3页 Journal of Psychiatry
基金 湖北省自然科学基金面上项目(编号:2015CFB694)
关键词 吲哚胺2 3-双加氧酶 细胞因子 创伤后应激障碍 Indoleamine 23-dioxygenase Cytokine Post-traumatic stress disorder
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献12

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二级参考文献31

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共引文献12

同被引文献39

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二级引证文献13

精神医学杂志
2015年 第5期

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