摘要
目的:评价芪蒌颗粒对气虚痰瘀阳虚证冠心病慢性心力衰竭患者的生活质量、情志障碍的影响。方法:将64例气虚痰瘀阳虚型冠心病慢性心力衰竭患者按1∶1随机列入对照组和治疗组。对照组予西药常规治疗,治疗组在西药常规治疗基础上加用芪蒌颗粒,疗程均为3个月。观察两组治疗前后6min步行试验(6MWT)、BNP、明尼苏达心力衰竭生活质量量表(LHFQ)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)等。结果:治疗后两组6min步行距离、BNP、LFHQ、HAMA、HAMD积分与治疗前比较有统计学差异(P<0.05),且治疗组优于对照组(P<0.05)。结论:芪蒌颗粒可改善冠心病慢性心力衰竭患者心功能,缓解焦虑、抑郁情绪,提高生活质量。
Objective： To evaluate clinical effect of Qilou Granule on life quality, anxiety and depression of coronary heart disease （CHD） patients with chronic heart failure. Methods： Sixty-four cases of CHD patients with chronic heart failure of qi deficiency, yang deficiency and phlegm stasis syndrome were randomly divided into treatment group and control group, with 32 cases in each group. Patients in control group accepted routine treatment of western medicine, while patients in treatment group accepted the Qilou Granule in addition to western medicine. After three months treatment, 6-minute walk test （6MWT）, BNP, Minnesota living with heart failure questionnaire （LHFQ）, Hamilton anxiety scale （HAMA） and Hamilton depression scale （HAMD） were used to measure the clinical effect of Qilou Granule in the trial. Results： The scores of 6-minute walk test, BNP, LHFQ, HAMA and HAMD in the treatment group were significant different before and after treatment （P〈0.05）. The result indicated that the treatment group was superior to the control group （P〈0.05）. Conclusion： Qilou Granule could improve the cardiac function, the mood of anxiety and depression and the quality of life of CHD patients with chronic heart failure.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2015年第11期4171-4173,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
上海市科学技术委员会科研计划项目(No.12401903403)~~
关键词
冠心病
慢性心力衰竭
生活质量
抑郁
焦虑
Coronary heart disease
Chronic heart failure
Life quality
Depression
Anxiety
