摘要
目的:探讨孕妇血清同型半胱氨酸(Hcy)浓度升高对胎儿的影响.方法:前瞻性研究176名孕妇早期的血清Hcy浓度及其围产儿关系,用循环酶法测量孕妇妊娠早期的血清Hcy浓度,以正常孕妇血清Hcy浓度的第75个百分位(P75)为界,分为高Hcy浓度组和正常Hcy浓度组,分析Hcy浓度与胎儿不良结局的关系.结果:妊娠早期血清Hcy浓度>7.53μmol/L,胎儿发生先天畸形、胎儿生长迟缓(FGR)的风险分别增加6.77(95%CI:1.41,32.52;P<0.05)和4.52(1.42,14.35;P<0.05)倍.结论:妊娠早期血清Hcy浓度升高是胎儿发生先天畸形、FGR危险因素.
Aim：Increased homocysteine has been reported to be associated with pregnancy outcome. The present study was designed prospectively to explore the effect of maternal homocysteine （Hcy）level on the fetus.Methods：This study included 176 pregnant women and their offspring.Maternal serum ho-mocysteine was measured in the first trimester of pregnancy by using enzymatic cycling assay.The mater-nal data and the pregnancy outcome were recorded.Results：Mothers with high serum Hcy levels at the first trimester of pregnancy were seven times [relative risk ratio,6.77 （95% confidence interval,1.41, 32.52）;P 〈0.05]more likely to give birth to a neonate with congenital abnormalities,and five times [4.52 （1.42,14.35）;P 〈0.05]with fetal growth retardation.Conclusion：Increased serum homocys-teine level in pregnant women was a risk factor for congenital abnormalities and fetal growth retardation.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
北大核心
2015年第5期417-420,共4页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
广东省科技计划项目(2010B31600107)
关键词
孕妇
高半胱氨酸(Hcy)
胎儿
先天畸形
胎儿生长迟缓
pregnant women
homocysteine （Hcy）
fetus
congenital abnormalities
fetal growth retardation
