摘要
目的:探讨急性心肌梗死患者血清25-羟维生素D3[25(OH)D3]与白介素-6(IL-6)、单核细胞趋化蛋白-1(MCP-1)、高敏C反应蛋白(hs-CRP)、白细胞计数(WBC)的相关性。方法:选取经冠脉造影确诊的急性心肌梗死患者224例(急性心肌梗死组)和200例冠脉正常者(冠脉正常组)作为研究对象,采用全自动生化仪测定各组生化指标;同时采用酶联免疫吸附实验检测各组血清25(OH)D3、IL-6、MCP-1水平,免疫比浊法检测血清hs-CRP水平,分析急性心肌梗死患者血清25(OH)D3与IL-6、MCP-1、hs-CRP、WBC水平的相关性。结果:与冠脉正常组比较,急性心肌梗死组患者血清BMI、SBP、DBP、cTnI、CK-MB、TG、TC、LDL-C、GLU、Hcy、IL-6、MCP-1、hs-CRP、WBC水平均明显升高,而25(OH)D3水平明显降低,差异有统计学意义(均P<0.01),进一步直线相关分析结果显示:急性心肌梗死患者血清25(OH)D3水平与IL-6、MCP-1、hs-CRP、WBC水平均呈明显负相关(r=-0.773、-0.721、-0.685、-0.620,均P<0.01)。结论:急性心肌梗死患者血清25(OH)D3水平明显降低,其与IL-6、MCP-1、hs-CRP、WBC呈明显负相关,炎症介质参与了心肌梗死的发生发展,25(OH)D3可能是心肌梗死的保护因素。
Objective： To investigate the correlation between 25 hydroxy vitamin Da [25 （OH）D3 ] and Interleukin-6 （IL- 6 ）, Monocyte chemotactie protein-1 （ MCP-1 ）, High-sensitivity c-reactive protein （hs-CRP）, White cells count （WBC） in patients with acute myocardial infarction. Methods：There are 424 patients were divided into acute myocardial infarction group （n=224） and control group （n=200） according to their Coronary angiography. The related biochemical indices were detected with automatic biochemical analyzer. The levels of serum 25（OH）D3、IL-6 and MCP-1 were measured by Enzyme-linked immunosorbent experiment. The levels of serum hs-CRP were measured by Immune turbidimetry. Re- sults： The BMI, SBP, DBP, cTnI, CK-MB, TG, TC, LDL-C, GLU, Hcy, IL-6, MCP- 1, hs-CRP, WBC in acute myocardial infarction group were higher than normal control group, the difference were significant（all P〈0.01）, but the levels of serum 25（OH）Da in acute myocardial infarction group were significantly lower than normal control group, the differ- ence were significant（P〈0. 01）. Pearson correlation analysis show that serum 25 （OH）D3 levels and II.-6, MCP-1, hs-CRP,WBC were negatively correlated in patients with acute myocardial infarction （r=-0. 773,-0. 721,-0. 685, - 0. 620, all P〈0.01）. Conclusion： The levels of 25 （OH） D3 was significantly decreased in acute myocardial infarction, it was negatively correlated with IIz6.MCP-1.hs-CRP.WBC and is thus a protecting factor for myocardial infarction.
出处
《医学理论与实践》
2015年第21期2881-2882,2890,共3页
The Journal of Medical Theory and Practice
