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固醇调节元件结合蛋白-1信号通路研究进展 被引量：8

Progress in the Study of Sterol Regulatory Element Binding Protein-1 Signal Pathway
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摘要 固醇调节元件结合蛋白-1(sterol regulatory element-binding protein-1,SREBP-1)是脂质代谢重要的核转录因子之一,主要调控脂肪酸、甘油三酯和胆固醇的生物合成。SREBP-1及其靶基因的异常表达能够引起胰岛素抵抗、糖尿病和脂肪肝等一系列代谢性疾病。因此,认识SREBP-1信号通路上下游各因素的表达调控作用就显得非常重要。该文总结了受SREBP-1调控表达的靶基因的特点,着重介绍了胰岛素等上游因子在SREBP-1调控过程中的作用,为指导治疗各类代谢性疾病提供新的思路。 Sterol regulatory element-binding protein-1 （SREBP-1） is one of the important nuclear transcription factors in lipid metabolism. SREBP-1 can regulate the biosynthesis of fatty acid, triglyceride and cholesterol. Abnormal expression of SREBP-1 and its target genes can cause a series of metabolic diseases such as insulin resistance, diabetes and fatty liver disease. Therefore, it is very important to know the role of various factors in SREBP-1 pathway. In this review, we summarize the feature of target genes regulated by SREBP-l, emphatically introduce the role of insulin and other upstream factors in regulating SREBP-1, which will contribute to a better idea for the guidance and treatment of various metabolism diseases.
作者 乔辉 刘庆平
机构地区 大连大学生命科学与技术学院辽宁省糖脂代谢研究重点实验室
出处 《中国细胞生物学学报》 CAS CSCD 2015年第10期1432-1440,共9页 Chinese Journal of Cell Biology
基金 国家自然科学基金(批准号:30971232)资助的课题~~
关键词 SREBP-1 胰岛素 靶基因 脂质代谢 sterol regulatory element binding protein-1 insulin target genes lipid metabolism
分类号 Q51 [生物学—生物化学]
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参考文献80

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二级参考文献58

  • 1Unger RH, Zhou YT. Lipotoxicity of β- cells in obesity and in other causes of fatty acid spillover. Diabetes, 2001, 50 (Suppl. 1): S118-S121.
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  • 8Rome S, Lecomte V, Meugnier E, Rieusset J, Debard C, Euthine V, Vidal H, Lefai E. Microarray analyses of SREBP-la and SREBP-lc target genes identify new regulatory pathways in muscle. Physiol Genomics, 2008, 34(3): 327-337.
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共引文献16

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引证文献8

二级引证文献30

中国细胞生物学学报
2015年 第10期

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