摘要
目的:观察孟鲁司特钠辅助治疗呼吸道合胞病毒(RSV)毛细支气管炎的疗效及安全性。方法:选取RSV毛细支气管炎患儿76例,按随机数字表法分为对照组(37例)与观察组(39例)。对照组患儿采用吸氧、镇静、退热、止咳祛痰及布地奈德混悬液、沙丁胺醇溶液雾化吸入等常规治疗,观察组患儿在对照组基础上加用孟鲁司特钠4 mg,qd。观察两组患儿临床疗效和咳嗽、哮喘、哮鸣音消失时间及住院时间,治疗前后血清半胱氨酸白三烯(CysLTs)水平变化、不良反应发生情况。结果:治疗后,观察组患儿临床总有效率(94.87%)显著高于对照组(78.38%),差异有统计学意义(P<0.05);观察组患儿咳嗽、哮喘、哮鸣音消失时间及住院时间均显著短于对照组,差异有统计学意义(P<0.05);两组患儿治疗后血清CysLTs水平均显著低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组患儿治疗期间均未见明显不良反应发生。结论:孟鲁司特钠辅助治疗RSV毛细支气管炎疗效较好,不良反应发生率低。
OBJECTIVE： To observe therapeutic efficacy and safety of montelukast sodium assistant treatment for respiratory syncytial virus （RSV） bronchiolitis. METHODS： 76 RSV bronchiolitis neonatus were included in this study and randomly divided into control group （37 cases） and observation group （39 cases）. Control group was treated with regular treatment, oxygen inhala- tion, sedation, abatement of fever, cough suppression, eliminating phlegm, Budesonide suspension, aerosol inhalation of Albuter- ol solution; observation group was additionally given montelukast 4 mg, qd, on the basis of control group. The clinical efficacy, cough, suffocative and wheezing rale disappearance time, length of stay were compared between 2 groups. The serum level of Cys- teinyl leukotrienes （CysLTs） before and after treatment and ADR were also compared between 2 groups. RESULTS： After treat- ment, total clinical efficacy of observation group （94.87%） was significantly higher than that of control group （78.38%）, with sta- tistical significance （P〈0.05） ; the time of couth, suffocative, wheezing rale disappearance and length of stay in observation group were significantly shorter than those of control group, with statistical significance （P〈0.05） ; after treatment, the serum level of CysLTs in 2 groups were both significantly lower than before, the observation group was lower than the control group, with statisti- cal significance （P〈0.05）. No obvious ADR was found in 2 group during treatment. CONCLUSIONS： Montelukast sodium assis- tant treatment for RSV bronchiolitis is effective with less ADR.
出处
《中国药房》
CAS
北大核心
2015年第32期4565-4567,共3页
China Pharmacy
关键词
呼吸道合胞病毒
毛细支气管炎
孟鲁司特钠
疗效
安全性
Respiratory syncytial virus
Bronchiolitis
Montelukast sodium
Therapeutic efficacy
Safety
