摘要
目的脑CT灌注成像(CTP)测量参数的稳定性对于颅脑疾病的正确诊断及评估具有重要意义。本文评价128层CT容积螺旋穿梭(VHS)模式下正常兔脑基底节CTP测量的一致性。材料与方法 10只健康新西兰成年大白兔,采用VHS模式进行颅脑CTP。分别由甲、乙2名放射科医师独立进行CTP后处理,感兴趣区置于基底节,灌注参数测量包括脑血容量(CBV)、脑血流量(CBF)、平均通过时间(MTT)。医师甲间隔30 d后进行第2次后处理及测量。比较两侧基底节灌注参数的差异、不同医师及同一医师2次测量灌注参数的差异,评价2名医师及同一医师2次测量灌注参数的一致性。结果 3次测量两侧基底节CBV、CBF、MTT比较,差异均无统计学意义(F=0.162、0.050、0.488,P>0.05)。医师甲、乙首次测量CBV、CBF、MTT值的ICC分别为0.84、0.81、0.79;医师甲前后2次测量CBV、CBF、MTT值的ICC分别为0.80、0.89、0.84,不同医师及同一医师不同时间测量结果一致性较好。结论使用同一后处理软件情况下,VHS模式正常兔脑基底节CTP灌注参数测量一致性较好,提示该方法可用于相关动物模型脑基底节血流动力学研究。
Purpose It is important to keep the consistency of CT perfusion imaging（CTP） measurement in the evaluation of intracranial disorders. The purpose of this paper is to probe into the consistency of basal ganglia hemodynamic characteristics in normal rabbits with CTP measurement in the mode of volume helical shuttle（VHS）. Materials and Methods Brain CTP scans of 10 healthy rabbits were carried out in the VHS mode. The images derived from CTP were separately analyzed by two radiologists（A and B） with different experiences. ROIs were placed in the bilateral basal ganglia of the subjects and parameters such as cerebral blood volume（CBV）,cerebral blood flow（CBF） and mean transit time（MTT） were measured three times in each rabbit. Thirty days later,radiologist A analyzed the CTP images again with the same method. Differences of parameters in bilateral basal ganglia measured by different radiologists at different periods were compared respectively and consistency of the measurements was further assessed. Results There was no significant difference among the three measurements of CBV,CBF and MTT in bilateral basal ganglia（F=0.162,0.050 and 0.488,P〉0.05）. The ICC of CBV,CBF and MTT measured by the two radiologists for the first time were 0.84,0.81 and 0.79; while the ICC of CBV,CBF and MTT measured by radiologist A twice were 0.80,0.89 and 0.84,which showed that the results had good consistency measured by different radiologists at different times. Conclusion With the same post-processing software,the consistency of CTP of basal ganglia in the VHS mode is satisfactory in healthy rabbits,which suggests this technique may be a suitable means in the evaluation of basal ganglia hemodynamics in animal models.
出处
《中国医学影像学杂志》
CSCD
北大核心
2015年第9期649-653,共5页
Chinese Journal of Medical Imaging
关键词
体层摄影术
螺旋计算机
脑血管造影术
脑
血流动力学
灌注成像
图像处理
计算机辅助
模型
动物
兔
Tomography
spiral computed
Cerebral angiography
Brain
Hemodynamics
Perfusion imaging
Image processing
computer-assisted
Disease models
animal
Rabbits
