摘要
目的探讨慢性心衰的老年患者不同NYHA心功能分级所对应的血清NT-pro BNP（氨基末端脑钠肽前体）、CK-MB（肌酸激酶同工酶）、MYO（肌红蛋白）、c Tn I2（心肌肌钙蛋白）水平差异。方法分析2011-01-2013-01在延安市宝塔区人民医院接受治疗的256例慢性心衰老年患者（观察组）的临床资料,并选取健康体检者作为对照组,采用NYHA（美国心脏病协会）将心功能划分为Ⅰ、Ⅱ、Ⅲ、Ⅳ级,比较入组受试者的NT-pro BNP、c Tn I2、CK-MB、MYO水平差异。结果本研究共纳入研究对象300例,其中包括观察组240例,对照组60例。对照组及不同NYHA分级的心衰患者五组之间的年龄（F=10.08,P〈0.01）、NT-pro BNP（F=518.0,P〈0.01）、LVEF（F=187.0,P〈0.01）数据均有着显著性的差异;不同NYHA分级的心衰患者组间c Tn I2（F=138.6,P〈0.01）、CK-MB（F=28.48,P〈0.01）、MYO（F=103.3,P〈0.01）水平均有着显著性的差异。结论血清学指标NT-pro BNP、CK-MB、MYO、c Tn I2的联合检测在心衰患者心功能分级的诊断方面具有重要的临床意义。
Objective Our retrospective study was aimed to analyze the diagnosis of Serological indexes（ including NT- pro BNP,CK- MB,MYO and c Tn I2） in the NYHA class of heart failure patients. Methods Clinical data of patients with heart failure received treatment at our hospital from 2011 to 2013 was retrospectively analyzed. Patients included were taken as the observe group and normal people were as control group. Heart failure patients were divided into 4 groups according to the NYHA class,Ⅰ class,Ⅱ class,Ⅲ class and IV class. The level of NT- pro BNP,CK- MB,MYO and c Tn I2 in enrolled subjects was compared. Results A total of 300 patients were retrospective analyzed,including 240 in observe group and 60 in control group. The level of age,NT- pro NBP and LVEF in enrolled subjects was with statistical difference. The level of CK- MB,MYO and c Tn I2 in different NYHA classes was with statistical difference. Conclusion The serological indexes including NT- pro BNP,CK- MB,MYO and c Tn I2 had a significant meaning in the diagnosis of the NYHA class of heart failure patients.
出处
《延安大学学报（医学科学版）》
2015年第3期16-18,共3页
Journal of Yan'an University:Medical Science Edition
