摘要
肝衰竭发病机制复杂,目前临床上缺乏有效的内科治疗手段.免疫介导的肝损伤在肝衰竭发病初期起重要作用,糖皮质激素作为免疫和炎症抑制剂,可作为治疗肝衰竭的方法之一,但激素用于肝衰竭治疗目前在临床上还存在较大争议.本文综述了近年来糖皮质激素用于肝衰竭治疗的最新进展,并对糖皮质激素用于肝衰竭治疗的争议焦点进行了讨论.
The pathogenesis of liver failure is complicated. Currently, there is a lack of effective measures for the treatment of liver failure. Immune-mediated liver injury plays an important role in the early pathogenesis of liver failure. As an immune and inflammatory inhibitor, glucocorticoids can be considered one of the methods for the treatment of liver failure. However, the application of steroids in the treatment of liver failure in current clinical practice is controversial. This paper summarizes the progress in glucocorticoid use for the treatment of liver failure in recent years. Besides, the focus of controversy on glucocorticoids for treatment of liver failure is also discussed.
出处
《世界华人消化杂志》
CAS
2015年第29期4611-4616,共6页
World Chinese Journal of Digestology
基金
科技部重大专项子课题基金资助项目
No.2012ZX10002007
国家自然科学基金资助项目
Nos.81171579
81371832~~
