摘要
目的了解泰州市孕妇碘营养状况，为今后在正常食用碘盐的情况下是否需要采取其他补碘措施及开展孕妇尿碘和甲状腺功能监测提供依据。方法2012年9月至2013年12月．在泰州市各市（区）妇幼保健所（院）和部分乡镇卫生院选择妊娠早（妊娠期〈4个月）、中（妊娠期4—7个月）、晚（妊娠期≥8个月）期各300名以上孕妇，依据知情同意原则．采集一次性尿样和血样，测定尿碘和血清促甲状腺激素（TSH）、甲状腺激素[游离三碘甲状腺原氨酸（n）、游离甲状腺激素（FT4）]。尿碘测定采用尿碘快速定量检测试剂盒法，甲状腺功能测定采用电化学发光法。根据孕妇甲状腺功能指标的95％参考值范围作为孕妇甲状腺功能评判依据。结果共调查孕妇997名，妊娠早、中、晚期孕妇分别为302、357、338名，尿碘中位数分别为124、129、119μg/L，妊娠晚期孕妇尿碘最低。妊娠早、中、晚期孕妇TSH中位数分别为2．03、2．18、2．22mU／L；飓分别为（4．39±0．66）、（4．06±0．61）、（3．92±0．61）pmol／L；F’r4分另0为（14．56±2．56）、（13．08±2D3）、（12．70士2．38）pmol／L。甲状腺功能异常率为4．91％（49／977），以亚临床甲状腺功能减退为主，占48．98％（24／49）。结论泰州市妊娠期妇女仍有部分存在碘营养不良状况，同时存在甲状腺功能减退倾向。在今后工作中，应进一步加强对妊娠期妇女补碘知识的宣传教育，并在孕早期开展尿碘和甲状腺功能的监测。
Objective To investigate iodine nutritional status of pregnant women of Taizhou City, in order to provide a basis for assessment whether normal consumption of iodized salt is needed, to take complement iodine measure and to carry out monitoring of urinary iodine and thyroid function in pregnant women. Methods Early pregnancy （gestation 〈 4 months）, medium （4 to 7 months gestation） and late （pregnancy ≥ 8 months） of each of more than 300 pregnant women were chosen from maternal and child health （hospital） and part of the township hospitals of Taizhou City （district） from September 2012 to December 2013. Based on the principle of informed consent, disposable urine and blood samples were collected, urine iodine and thyroid hormone [serum thyroid stimulating hormone （TSH）, three free triiodothyronine （FT3） and free thyroid hormone （FY4）] were measured. Urinary iodine was measured using a urinary iodine rapid quantitative detection kit, thyroid function was measured by an electrochemical method. Use 95% of the reference value range of thyroid function in pregnant women as the basis for evaluation of thyroid function in pregnant women. Results A total of 997 pregnant women were investigated, early stage, medium-term and late pregnancy women were 302, 357 and 338, respectively. The median urinary iodine was 124, 129, 119 μg/L, pregnant women in late pregnancy had the lowest iodine urine. The median TSH of early stage, medium-term and late pregnancy women were 2.03, 2.18, 2.22 mU/L; the mean FT3 and FT4 of the three groups were （4.39 ± 0.66）, （4.06 ±0.61）, （3.92 ± 0.61）pmol/L and （14.56 ±2.56）, （13.08 ±2.03）, （12.70± 2.38）pmol/L, respectively. The rate of abnormal thyroid function was 4.91% （491977）, mainly in subhypothyroidism [48.98% （24/49）]. Conclusions Poor iodine-nutritional status exists in some pregnant women in Taizhou City. It is necessary to strengthen the propaganda and education of pregnant women on iodine supplement knowledge in the future, and carry out routine monitoring of urinary iodine and thyroid function in early pregnancy.
出处
《中华地方病学杂志》
CAS
CSCD
北大核心
2015年第11期829-832,共4页
Chinese Journal of Endemiology
基金
江苏省2011年血地寄防应用性科研课题（X201118）
关键词
孕妇
碘营养状况
甲状腺功能
Pregnant woman
Iodine-nutrition status
Thyroid function
