摘要
目的分析天津市疑似预防接种异常反应(AEFI)主动监测数据的发生特征,评价同期被动监测系统的敏感性。方法 2011—2013年,分层选择4个区县的8家接种门诊作为主动监测点,通过主动回访收集到的AEFI为主动监测AEFI数据,通过全国信息系统收集全市范围自愿就医的被动监测数据。组织AEFI调查诊断专家组对除明确诊断为一般反应以外的AEFI开展调查诊断分类。结果共有效主动监测32 698例,AEFI病例235例,发生率为718.70/10万剂。3年间AEFI主动监测发生率差异无统计学意义(849.01/10万剂vs 599.32/10万剂vs 686.72/10万剂,χ2=5.07);被动监测AEFI 4 164例,发生率为34.09/10万剂;3年间AEFI被动监测发生率逐年上升(20.05/10万剂vs 31.35/10万剂vs 50.51/10万剂,χ2=572.02,P<0.05);各年度主动监测AEFI发生率均高于被动监测(均P<0.05)。主动监测AEFI的一般反应所占比例(95.32%)高于被动监测(85.09%),异常反应低于被动监测(3.83%vs13.32%,均P<0.05),偶合症、心因性反应差异均无统计学意义。二者均未监测到疫苗质量事故和接种事故,AEFI发生率居前5位的疫苗中均有7价肺炎、麻疹、进口百白破疫苗。结论 AEFI主动监测可发现更多的轻微一般反应,天津市被动监测系统的敏感性逐年上升,能够满足工作需求。应建立针对严重AEFI病例的统一分类诊断标准。
Objective To analyze the occurrence features of the active surveillance of adverse events following immu-nization （AEFI） in Tianjin, and evaluate the sensitivity of passive surveillance systems over the same period. Methods The layered eight vaccination clinics of four counties were selected as active surveillance points. The data of active surveillance AEFI were collected through telephone investigation in 2011-2013. The data of passive surveillance was collected through the national AEFI information management system. The descriptive methodology and chi square test were used. Results A total of 235 cases were collected through active surveillance in 2011-2013. The AEFI incidence rate was 718.70 per 100 000 doses,no difference in the incidence between three years（χ2=5.07）. A total of 4164 cases were collected through passive sur-veillance. The incidence rate was 34.09 per 100 000 doses,the incidence increased year by year（χ2=572.02,P〈0.05）. In ac-tive surveillance cases, 95.32%was the common vaccine reaction, 3.83%was the rare vaccine reaction, no serious vaccinereaction. In passive surveillance cases, the common vaccine reaction, the rare vaccine reaction were 85.09%and 13.32%. The serious vaccine reaction was found in 44 cases. Conclusion The more slightly common vaccine reaction can be found by active surveillance. The sensitivity of Tianjin passive surveillance system is increasing year by year, which can meet the requirements for job. The classification and diagnostic criteria of the serious vaccine reaction need to be established.
出处
《天津医药》
CAS
2015年第11期1330-1333,共4页
Tianjin Medical Journal
关键词
疫苗
疑似预防接种异常反应
主动监测
被动监测
天津
vaccines
adverse events following immunization
active surveillance
passive surveillance
Tianjin
