摘要
目的采用磁共振弥散张量成像(DTI)及氢质子磁共振波谱(1 H-MRS)方法探讨2型糖尿病(T2DM)患者双侧半卵圆中心白质结构及代谢产物的改变。方法收集T2DM患者(T2DM组)和健康体检人员(对照组)各30例,行MRS及DTI检查,测量双侧半卵圆中心ADC值与FA值,N乙酰天门冬氨酸(NAA)、肌酸(Cr)和胆碱(Cho)的含量,计算NAA/Cr、Cho/Cr、Cho/NAA比值,并比较两组间差异。结果T2DM组左、右侧半卵圆中心ADC值升高(t=9.51、2.06)、FA值降低(t=6.08、3.67)、NAA/Cr值降低(t=3.06、2.31)、Cho/NAA升高(t=5.68、2.24),左侧半卵圆中心Cho/Cr升高(t=5.67),与对照组比较差异均有统计学意义(P均<0.05)。结论 DTI联合MRS可反映T2DM患者双侧半卵圆中心局部神经纤维结构及代谢产物的异常改变;DTI联合MRS技术可早期发现由T2DM引发的认知功能损害。
Objective To explore the changes of white matter structure and metabolic product in patients with type 2diabetes mellitus（T2DM）patients using proton magnetic resonanc spectroscopy（1 H-MRS）and diffulsion tensor imaging（DTI）.Methods T2 DM patients（T2DM group,n=30）and healthy controls（control group,n=30）were examined by the same methods with MRI,DTI and MRS.The ADC and FA,N-acetyl aspartic（NAA）,creatine（Cr）,choline（Cho）were measured.The FA,ADC,NAA/Cr,Cho/Cr,Cho/NAA between two groups were compared.Results Compared with the control group,ADC increased（t=9.51、2.06）,FA significant declined（t=6.08,3.67）,NAA/Cr declined（t=3.06,2.31）,Cho/NAA increased（t=5.68,2.24）,the left Cho/Cr increased（t=5.67）,there were statistically significant differences（all P〈0.05）.Conclusion Combination of DTI and MRS can be used to show the changes in micro neural structure and metabolism,early injury of cognitive function can be detected as well.
出处
《中国医学影像技术》
CSCD
北大核心
2015年第11期1635-1638,共4页
Chinese Journal of Medical Imaging Technology
关键词
糖尿病
2型
轻度认知功能障碍
扩散磁共振成像
磁共振波谱
Diabetes mellitus
type 2
Mild cognitive impairment
Diffusion magnetic resonance imaging
Magnetic resonanc spectroscopy
