摘要
目的 采用Meta分析的方法对东亚人群ABCG2基因rs2231142位点多态性与痛风相关性研究进行分析.方法 截至2014年12月,计算机检索英文数据库（PubMed、EMbase）及中文数据库[中国知网（CNKI）、维普期刊资源整合服务平台（VIP）和万方数据知识服务平台（Wanfang）、中国生物医学文献服务系统（SinoMed）]中rs2231142位点基因多态性与痛风相关性研究.采用Stata 12.0软件进行Meta分析.结果 最终纳入9篇文献.Meta分析显示,rs2231142位点基因多态性在等位基因、杂合子和纯合子比较模型下均与痛风患病风险增加相关,合并OR值（95％CI）分别为2.04（1.82 ～ 2.28）、1.97（1.57 ～ 2.48）和3.71（3.07 ～ 4.47）.按性别和地区进行亚组分析后,异质性有一定减少.结论 rs2231142位点基因多态性与东亚人群痛风相关,A等位基因是东亚人群发生痛风的危险基因.
Objective To systematically evaluate the association between single nucleotide polymorphism of rs2231142 genetic susceptibility and gout in East Asian population.Methods The literature retrieval was conducted by using English databases （Medline, EMbase）, Chinese databases （CNKI, Vip, Wanfang, SinaMed） and others to collect the published papers on the association between single nucleotide polymorphism of rs2231142 genetic susceptibility and gout by the end of December 2014.Meta-analysis was performed with software Stata 12.0.Results Nine studies were included.There were significant associations between increased risk of gout and single nucleotide polymorphism of rs2231142, the combined OR was 2.04 （95% CI： 1.82-2.28）for A allele and C allele, 1.97 （95% CI： 1.57-2.48） for CA and CC, 3.71 （95% CI： 3.07-4.47） for AA and CC.Sex and region specific subgroup analysis showed less heterogeneity.Conclusion There is significant association between gout and single nucleotide polymorphism of rs2231142 in East Asian population,and A allele is a high risk gene for gout.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2015年第11期1291-1296,共6页
Chinese Journal of Epidemiology
基金
国家自然科学基金（81072355）
北京市科委项目（D121100004912003）
科技部“973”项目（2013CB530800）
