摘要
胰腺癌是癌症死亡的第四大原因,它的特点是早期浸润和转移。上皮间质转化的发展过程对肿瘤的迅速进展有潜在的意义。在上皮间质转化过程中,肿瘤细胞失去上皮特征并获得间质细胞的特性,如增强的运动和侵袭能力。本篇综述将讨论胰腺癌中与上皮间质转化相关的最新研究成果,重点讲述上皮间质转化存在于胰腺癌中的证据和它的分子特性,以及EMT与肿瘤干细胞和耐药性之间的关系。
Pancreatic carcinoma is the fourth- leading cause of cancer death and is characterized by early invasion and metastasis. The developmental program of epithelial - mesenchymal transition （EMT） is of potential importance for this rapid tumor progression. During EMT, tumor cells lose their epithelial characteristics and gain properties of mesenchymal cells, such as enhanced motility and invasive features. This review will discuss recent findings pertinent to EMT in pancreatic carcinoma. Evidence of the existence of EMT in pancreatic carcinoma and it＇s molecular charac- teristics will be outlined, as well as the connection of EMT to related topics, cancer stem cells and drug resistance.
出处
《现代肿瘤医学》
CAS
2015年第24期3698-3700,共3页
Journal of Modern Oncology
关键词
上皮间质转化
胰腺癌
肿瘤进展
肿瘤干细胞
耐药性
epithelial - mesenchymal transition, pancreatic adenocarcinoma, tumor progression, cancer stem cells,chemoresistance ~ , ＇ ＇
