摘要
目的研究不同分期小细胞肺癌患者血钙水平与外周血循环肿瘤细胞(CTC)的检测价值。方法选择我院84例小细胞肺癌患者为研究对象。根据国际肺癌的诊断标准对患者进行分期,局限期患者33例,广泛期患者51例。对所有患者血钙水平与外周血循环肿瘤细胞水平进行检测。结果患者的体内的血清钙以及游离钙在广泛期明显多于局限期,P<0.05。患者的外周血循环肿瘤细胞≥1和≥5,广泛期明显多于局限期,P<0.05。患者的血钙以及外周血循环肿瘤细胞水平会随病情发展而增加,P<0.05各项指标和病情的发展程度呈现出正相关关系。结论综上所述,对小细胞肺癌患者体内血钙以及外周血循环肿瘤细胞水平的检测价值较高。对于患者的早期确诊,治疗以及病情的预后评价具有十分重要的意义。
Objective To study the value of detection of blood calcium and peripheral blood circulating tumor cells in small cell lung cancer. Methods 84 small cell lung cancer patients from April 2013 to April 2014 were selected as the research objects. According to the international diagnostic criteria they were staged into two groups, the limited period group with 33 cases, and the extensive group with 51 cases. Their blood calcium and circulating tumor cells in peripheral blood were measured. Results The levels of serum calcium and calcium were significantly higher in the in the extensive stage group than in the limitation group （P〈0. 05）. Patients with circulating tumor cells in peripheral blood of aged 1 and above 5 were significantly more in the in the extensive stage group than in the limitation group （P〈0. 05）. Serum calcium and circulating tumor cells in peripheral blood increased with the progression of the disease, and they showed positive correlations with the development of the disease （P〈0. 05）. Conclusion In summary, the detection of serum calcium and circulating tumor cells has certain significance in patients with small cell lung cancer, which is very important for the evaluation of prognosis and the treatment of the disease.
出处
《临床肺科杂志》
2015年第12期2138-2140,共3页
Journal of Clinical Pulmonary Medicine
关键词
不同分期
小细胞肺癌
血钙
外周血循环
肿瘤细胞
different stages
small cell lung cancer
serum calcium
circulating tumor cells
