摘要
目的：探讨中医辨证分型对膝骨性关节炎（KOA）患者的免疫状况和治疗效果。方法：选择2013年4月~2014年10月来我院进行膝骨性关节炎治疗的患者140例,并按照患者的入院顺序将其分为观察组（n=90）和对照组（n=50）,观察组患者进行中医辨证分型治疗,对照组口服扶他林片。比较患者治疗前后IL-1、IL-6变化,患者的不良反应和治疗效果。结果：四组患者治疗后IL-1、IL-6均有所减少,与治疗前比较差异据有统计学意义（P〈0.05）;且治疗后肾虚髓空组和阳虚寒凝组均低于瘀血阻滞组,肾虚髓空组最低,与对照组比较,差异有统计学意义（P〈0.05）;观察组治疗效果明显提高,其治疗总有效率达到了95.6%,而对照组仅为88%,两组患者治疗效果比较,差异具有统计学意义（u=3.6255,P=0.0003）;观察组在头晕、肠胃反应、心律失常及感染方面的总不良反应率为14.3%,较对照组46%的总不良反应率而言有明显的减少,两组患者不良反应比较差异据有统计学意义（P〈0.05）。结论：对膝骨性关节炎患者进行中医辨证分型治疗,能有效改善患者IL-1、IL-6等炎性因子,提高免疫能力和临床治疗效果。
Objective： To investigate the immune status and the effect of TCM syndrome differentiation in patients with knee osteoarthritis（ KOA）. Methods： Choosing 140 cases of patients with knee osteoarthritis from April 2013 to October 2014,and in accordance with the order of admission,the patient will be the observation group（ n = 90） and the controlled group（ n = 50）,patients in the study group were treated with TCM syndrome differentiation treatment,the controlled group oral Voltaren tablets.The adverse reactions and the treatment effect of the patients were compared with the changes of IL-6and IL-1before and after the treatment. Results： Four groups of patients after treatment of IL-1,IL-6decreased,compared with before treatment,the difference had statistical significance（ P〈0. 05）; and after the treatment of kidney marrow empty group and Yang deficiency cold coagulation group were lower than blood stasis group,kidney marrow empty group was the lowest,compared with the controlled group,the difference was statistically significant（ P〈0. 05）; observing the effect of the treatment group was obviously improved,the total effective rate reached 95. 6%,while the controlled group was only 88%,compared with the treatment effect of the two groups,the difference was statistically significant（ u = 3. 6255,P = 0. 0003）; the observation group in the total adverse reaction of gastrointestinal reactions,dizziness,arrhythmia and the infection rate was 14. 3%,significantly decreased compared with the controlled group in terms of total adverse reaction rate of 46%,the differences of the adverse reactions of the two groups had statistical significance（ P〈0. 05）. Conclusion： The treatment of TCM syndrome differentiation in patients with knee osteoarthritis can effectively improve the inflammatory factors such as IL-6and IL-1,and improve the immune and clinical therapeutic effect.
出处
《四川中医》
2015年第11期81-83,共3页
Journal of Sichuan of Traditional Chinese Medicine
关键词
膝骨性关节炎
中医辨证分型
免疫状况
治疗效果
Knee osteoarthritis
TCM syndrome differentiation
Immune status
Treatment effect
