摘要
目的探讨疏血通注射液联合氯吡格雷治疗缺血性脑卒中的疗效及对患者神经功能与血液流变学的影响。方法 160例符合纳入标准的缺血性脑卒中患者按随机数字表法分为对照组(n=80)和观察组(n=80)。常规治疗基础上,对照组给予氯吡格雷治疗,观察组在对照组的基础上联合应用疏血通注射液治疗。观察比较两组患者临床疗效、反映神经功能的美国国立卫生研究院卒中量表(NIHSS)评分、血液流变学及不良反应发生情况。结果观察组的治疗总有效率为86.2%,明显高于对照组的72.5%(P<0.05)。与对照组相比,观察组治疗后NIHSS评分明显降低,血液流变学指标全血高切黏度、全血低切黏度、血浆黏度、红细胞最大聚集指数、血细胞比容明显下降,比较差异均有统计学意义(均P<0.05)。治疗过程中,未出现严重不良反应,观察组的不良反应发生率为10.0%,与对照组5.0%的不良反应发生率比较差异无统计学意义(P>0.05)。结论疏血通注射液联合氯吡格雷治疗缺血性脑卒中疗效可靠,能够显著提高临床疗效,改善神经功能及血液流变学指标,且不良反应轻微,临床上值得进一步研究。
Objective To investigate the clinical effect of Shuxuetong Injection combined with clopidogrel in the treatment of ischemic stroke and its influence on the neurological function and hemorheology.Methods 160 cases of ischemic stroke meeting the inclusion criteria were randomly divided into the control group（n=80）and the observation group（n=80）according to random number table method.Besides the conventional treatments,the control group was given clopidogrel,while the observation group was given Shuxuetong Injection combined with clopidogrel.Then,the curative efficacy,score of national institute of health stroke scale（NIHSS）reflecting neurological function,hemorheological parameters and adverse reactions were compared between the two groups.Results The observation group had a total therapeutic efficiency rate of 86.2%,which was significanty higher than 72.5% in the control group（P〈0.05）.After treatment,the score of NIHSS in the observation group was significanty lower than that in the control group（P〈0.05）.As to the hemorheological parameters,the whole high blood viscosity,whole low blood viscosity,plasma viscosity,maximum aggression index of erythrocyte,and hematocrit in the observation group were significanty lower in comparison with the control group,the differences were statistically significdnt（P〈0.05）.During treatment,no severe adverse reactions occurred.And the incidence rate of adverse reactions in the observation group was 10.0%,which in the control group was 5.0%,but without statistical difference between them（P〉0.05）.Conclusion The combined therapy of Shuxuetong Injection and clopidogrel is effective for treating ischemic stroke,can significantly increase the curative efficacy,improves the neurological function and hemorheologic indexes with mild adverse reactions and deserves to be further researched in clinic.
出处
《检验医学与临床》
CAS
2015年第21期3189-3191,共3页
Laboratory Medicine and Clinic
