摘要
【目的】观察阿奇霉素联合布地奈德雾化吸入治疗小儿闭塞性细支气管炎（Bronchiolitis obliterans，B0）的临床效果。【方法】收集2011年4月至2014年6月本科收治的临床诊断为B0的患儿56例，采用随机数字表法将其分为观察组与对照组，每组各28例，两组患儿均给予退热、化痰和止咳等药物进行常规对症支持治疗。对照组给予布地奈德雾化吸入治疗，观察组采用阿奇霉素联合布地奈德雾化吸入治疗，测量两组患儿治疗前后喘息控制情况及临床表现总得分，比较两组患儿治疗期间发生气喘次数、感染次数及两组患儿的临床治疗效果。【结果】观察组与对照组患儿在治疗前的喘息得分及临床表现总得分之间的差异无统计学意义（P〉0．05），而治疗后观察组的喘息控制得分及临床表现总得分均较对照组的低且差异具有统计学意义（P〈0．05）；观察组治疗期间的气喘发生率为14．3％，感染发生率为10．7％，而对照组分别为39．3，35．7％，两组间比较差异均有统计学意义（P〈0．05）；观察组的总有效率为89．3％明显高于对照组的64．3％，差异具有统计学意义（χ^2=4．909，P=0．027）。【结论】阿奇霉素联合布地奈德雾化吸入治疗小儿BO的临床效果显著，推荐在临床上应用。
[Objective]To observe the clinical effect of azithromycin combined with budesonide inhalation in treating children with bronchiolitis obliterans and provide a reference for the clinical treatment. [Methods]56 children clinically diagnosed with bronchiolitis obliterans were recuited from our department, then divided randomly into an observation therapy group （28 patients） and a control treatment group（28 patients）o Both groups of patients were given antipyretic, phlegm and cough medicine for conventional symptomatic and supportive treatment. In Addition, control group patients were treated with budesonide inhalation, while observation therapy group patients were also treated with a combination of azithromycin and budesonide inhalation. Breathing control test scores and the total scores of clinical manifestations before and after treatment in the two groups were measured and the times of infection and asthma and the clinical curative effect between the two groups after treatment were recorded. [Results]The wheezing scores and the total score of clinical manifestations between the observation group and the control group before treatment had no statistical significance （ P 〉0.05）. The wheezing scores and the total score of clinical manifestations in the observation group after treatment was lower than those of the control group; the differences were statistically significant （ P 〈0.05）. The asthma incidence rate in the observation group during the treatment was 14.3% and the infection rate was 10.7%, while the asthma incidence rate in the control group was 39.3% and infection rate was 35.7 %. Differences in rates of asthma and infection incidence between the two groups were statistically significant （ P 〈0.05）; the overall efficacy of the observation group after treatment was 89.3 %, while the efficacy of the control group was 64.3%. This showed statistically significant differences between the two groups （χ^2 =4.909, P =0.027）. [Conclusion]The clinical effect of azithromycin combined With budesonide inhalation in treating children with bronchiolitis obliterans is significant and is recommended for clinical application.
出处
《医学临床研究》
CAS
2015年第10期1983-1985,共3页
Journal of Clinical Research
