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帕金森病患者血浆α-synuclein、Aβ及tau蛋白变化特点 被引量:3

Characteristics of α-synuclein, Amyloid-β and Tau Proteins in the Plasma of Patients with Parkinson's Disease
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摘要 目的:探索帕金森病(Parkinson's disease,PD)患者血浆中α-突触核蛋白、Aβ及tau蛋白变化情况。方法:募集2014年4月至2015年4月来我院就诊的PD患者62例,正常对照人群59例,采集两组人群的基本临床信息,测定血浆中α-突触核蛋白、Aβ40、Aβ42、p T181-tau蛋白、p T231-tau蛋白和总tau蛋白浓度,比较两组之间的差异,同时进行相关性分析。结果:PD患者血浆α-突触核蛋白和p T181-tau蛋白浓度显著高于对照组(P值分别为0.001,0.019),而两组间Aβ40、Aβ42、p T231-tau蛋白和总tau蛋白浓度无明显差异(P>0.05)。相关性分析提示PD患者血浆α-突触核蛋白和p T181-tau蛋白浓度与患者年龄、性别、教育程度、病程、高血压、糖尿病、Hoehn/Yahr分级及Schwab&England评分无相关性(P>0.05)。结论:虽然PD患者血浆α-突触核蛋白和p T181-tau蛋白高于正常对照组,但尚不适宜作为PD的生物标志物。 Objective: To investigate the changes in the levels ofα-synuclein, amyloid-β (Aβ) and tau proteins in the plasma of patients with Parkinson's disease. Methods: The study was carded out on patients with Parkinson's disease (PD) and normal controls (NC). Participants with PD (n=59), NC (n=62) were consecutively recruited during a 1-year period from April 2014 to April 2015 from Daping Hospital, and the clinical data were collected. The concentrations of α-synuclein, amyloid-β and tau proteins in the plasma of PD and NC groups were measured and compared between two groups. Moreover, correlation analysis was also performed. Results: The concentrations of α-synuclein and tau phosphorylated at threonine 181 (pT 181-tau) in the PD group were significantly higher than those in the NC group (P=0.001, 0.019, respectively). There were no significance differences in the concentrations of Aβ40, Aβ42, pT231-tau and total-tau between two groups (P〉0.05). Correlation analysis indicated that et-synuclein and pT181-tau did not correlated with age, gender, education, disease duration, hypertension, diabetes, Hoehn and Yahr stage and Schwab & England score (P〉0.05). Conclusions: Although the plasma levels of α-synuclein and pT181-tau were found to be increased in PD patients, they seem not be capable of being biomarkers for PD.
出处 《现代生物医学进展》 CAS 2015年第33期6472-6475,共4页 Progress in Modern Biomedicine
基金 中国博士后基金项目(2012M521861 2013T60955) 重庆博士后基金项目(Xm201342)
关键词 帕金森病 Α-突触核蛋白 Β淀粉样肽 TAU蛋白 Parkinson's disease α-synuclein Amyloid-β Tau proteins
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