摘要
目前海洋药物学的研究如火如荼,研究有特异活性的海洋天然产物,获取这类成分为人类提供新药,成为目前的研究重点。间苯三酚是一种重要的医药中间体,在海洋藻类中广泛存在,尤其在褐藻门中。作为一种亲肌性非阿托品非罂粟碱类平滑肌解痉药,主要用于治疗多种急性痉挛性疼痛。是胃肠道、泌尿生殖道痉挛及孕期宫缩治疗的首选药物,作用迅速,副作用少。目前主要通过化学法合成,但是由于化学法存在各种弊端,生物合成法成为制备间苯三酚的潜在手段和研究热点。就间苯三酚的化学合成法以及生物合成机制和制备方法进行了综述,并对间苯三酚的主要应用进行了归纳总结。
The marine pharmacology research is getting stronger and stronger. Recent research has focused on the study of specific activity of marine natural products, and applied to new drugs for human. Phloroglucinol is a kind of important pharmaceutical intermediates. It is widely distributed in marine alga, especially in Phaeophyta. As a non-atropine non-papaverine class smooth muscle spasmolysis medicine, phloroglucinol primarily treat a variety of acute spasmodic pain. It is the first choosed drug in the treatment of gastrointestinal, genitourinary tract spasms and contractions during pregnancy, for its fast-acting, less side effects. Now, phloroglucinol is mainly produced by chemical synthesis. But the chemical method has many disadvantages, so biological synthesis become a potential method and research hot spot to produce phloroglucinol. The mechanisms and the methods of phloroglucinol biosynthesis are reviewed. In addition, it also sums up the main applications of phloroglucinol.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2015年第10期115-121,共7页
China Biotechnology
基金
海洋生物医药间苯三酚等制剂国际化发展能力建设项目(鲁财建指[2014]18号)资助项目
关键词
间苯三酚
化学合成
生物合成
应用
Phloroglucinol Chemical synthesis Biosynthesis Application
