期刊文献+

多聚磷酸盐在细菌和哺乳动物细胞中的作用 被引量:4

The role of polyphosphate in bacteria and mammalian cells
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摘要 多聚磷酸盐(Poly P)广泛分布于真核生物和原核生物中,是由几十个到几百个无机磷酸盐单体通过高能磷酸键聚合而成的线性多聚体。Poly P能影响细菌的毒力,有助于细菌抵抗环境中的压力刺激。在真核细胞中,Poly P与核仁的转录相关,可促进凝血和细胞分化、调节促炎反应,并和骨的重构、矿化及去矿化相关。同时,Poly P也是线粒体通透性转换孔的激活物。本文综合阐述Poly P在微生物及哺乳动物中的作用及相关机制,同时结合我们的研究工作,分析Poly P对大肠杆菌致病性的影响,以期引起研究者对Poly P的关注。 Inorganic polyphosphate(Poly P), is a linear chain of tens or many hundreds of phosphate residuals linked by high-energy phosphoanhydride bonds, and widely exist in prokaryotes and eukaryotes. Many researches demonstrated that Poly P can affect the virulence of bacteria, and help bacteria to survive in nutrient-deficient environment. Poly P has been identified to be related with the RNA transcription in nucleolus of eukaryotes. Poly P can also promote cell differentiation and modulate inflammatory response. Additionally, Poly P is related to mineralization and demineralization of vertebrate bones. Poly P is the activator of mitochondrial permeability transition pore. This review is aim to summarize the impacts of Poly P to microorganism or mammal, and get more attention for the importance of Poly P.
出处 《微生物学通报》 CAS CSCD 北大核心 2015年第11期2223-2228,共6页 Microbiology China
基金 国家自然科学基金项目(No.30972637 81200505) 国家级大学生创新创业训练计划项目(No.201212121092) 广东省"大学生创新实验计划"项目(No.1212111027)
关键词 多聚磷酸盐 细菌 哺乳动物细胞 多聚磷酸盐激酶 Polyphosphate Bacteria Mammalian cells Polyphosphate kinase
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参考文献25

  • 1石廷玉,王怀林,谢建平.多聚磷酸盐及其代谢酶的研究进展[J].生理科学进展,2011,42(3):181-187. 被引量:10
  • 2Varela C, Mauriaca C, Paradela A, et al. New structural and functional defects in polyphosphate deficient bacteria: a cellular and proteomic study[J]. BMC Microbiology, 2010, 10(2): 7.
  • 3Rashid MH, Kornberg A. Inorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosa[J]. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97(9): 4885-4890.
  • 4Fraley CD, Rashid MH, Lee SSK, et al. A polyphosphate kinase I (ppkl) mutant of Pseudomonas aeruginosa exhibits multiple ultrastructural and functional defects[J]. Proceedings of the National Academy of Sciences of the United States of America, 2007,104(9): 3526-3531.
  • 5Shi TY, Fu TW, Xie JP. Polyphosphate deficiency affects the sliding motility and biofilm formation of Mycobacterium smegmatis[J]. Current Microbiology, 2011, 63(5): 470-476.
  • 6Grillo-Puertas M, Villegas JM, Rintoul MR, et al. Polyphosphate degradation in stationary phase triggers biofilm formation via LuxS quorum sensing system in Escherichia coU[J]. PLoS One, 2012, 7(11): e50368.
  • 7Yang ZX, Zhou YN, Yang Y, et al. Polyphosphate binds to the principal sigma factor of RNA polymerase during starvation response in Helicobacter pylori[J]. Molecular Microbiology, 2010,77(3): 618-627.
  • 8Thayil SM, Morrison N, Schechter N, et al. The role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistence[J]. PLoS One, 2011, 6(11): e28076.
  • 9杨诏旭,路程伊,杨宾,夏宁,窦科峰.敲除PPK基因对幽门螺杆菌逃避巨噬细胞免疫清除的影响[J].世界华人消化杂志,2012,20(1):22-26. 被引量:2
  • 10Rashid MH, Rumbaugh K, Passador L, et al. Polyphosphate kinase is essential for biofilm development, quorum sensing, and virulence of Pseudomonas aeruginosa[J]. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97(17): 9636-9641.

二级参考文献84

  • 1Gomez-Garcia MR, Zhang HY, Rao NN, et al. Inorganic polyphosphate in Dictyostelium discoideum. FASEB J, 2006, 20 : A900.
  • 2Lichko LP, Kulakovskaya TV, Kulaev IS. Inorganic polyphosphate and exopolyphosphatase in the nuclei of Saccharomyces cerevisiae: dependence on the growth phase and inactivation of the PPX1 and PPN1 genes. Yeast, 2006, 23 : 735- 740.
  • 3Itoh H, Kawazoe Y, Shiba T. Enhancement of protein synthesis by an inorganic polyphosphate in an E. coli cell-free system. J Microbiol Methods, 2006, 64 : 241 -249.
  • 4Gomez-Garcia MR, Kornberg A. Formation of an actin-like filament concurrent with the enzymatic synthesis of inorganic polyphosphate. Proc Natl Acad Sci, 2004, 101 : 15876 15880.
  • 5Fang JM, Ruiz FA, Docampo M, et al. Overexpression of a Zn^2+-sensitive soluble exopolyphosphatase from Trypanosoma cruzi depletes polyphosphate and affects osmoregulation. J Biol Chem, 2007, 282 : 32501 -32510.
  • 6Pestov NA, Kulakovskaya TV, Kulaev IS. Inorganic polyphosphate in mitochondria of Saccharomyces cerevisiae at phos- phate limitation and phosphate excess. FEMS Yeast Res, 2004, 4 : 643 - 648.
  • 7Zakharian E, Reusch RN. Haemophilus influenzae outer membrane protein P5 is associated with inorganic polyphos- phate and polyhydroxybutyrate. Biophys J, 2007, 92 : 588 - 593.
  • 8Li L, Rao NN, Kornberg A. Inorganic polyphosphate essential for lytic growth of phages P1 and fd. Proc Natl Acad Sci, 2007, 104 : 1794- 1799.
  • 9Mclnerney P, Mizutani T, Shiba T. Inorganic polyphosphate interacts with ribosomes and promotes translation fidelity in vitro and in vivo. Mol Microbiol, 2006, 60 : 438 - 447.
  • 10Holbein S, Freimoser FM, Werner TP, et al. Cordycepinhypersensitive growth links elevated polyphosphate levels to inhibition of poly (A) polymerase in Saccharomyces cerevisiae. Nucleic Acids Res, 2008, 36 : 353-363.

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