摘要
尽管子宫内膜异位症(EMs)的病因不明确,其普遍可接受的病理生理学理论是经血逆流。但经血逆流只发生于部分EMs患者中,这提示EMs的发生还有其他因素。二噁英是指那些能与芳香烃受体结合、结构和性质相似的同类物或异构体的两大类有机化合物。二噁英能够增强雌激素作用,降低孕激素抑制子宫内膜异位的作用,促进T细胞表达、分泌CCL趋化因子(regulated on activation,normal T-cell expressed and secreted,Rantes)、子宫基质细胞金属蛋白酶(matrix metalloproteinase,MMP)、MMP-2、肿瘤坏死因子-α(TNF-α)。许多实验室和基于人群的研究表明,暴露于环境毒物也许是子宫内膜异位的诱因之一。
Although the etiology of endometriosis （EMs） is uncertain, it is widely accepted that the pathophysiology of EMs is retrograde menstruation. However, not all retrograde menstruation contributes to EMs, which suggests that other factors may be related to the occurrence of EMs. Dioxins are those which can be combined with the aromatic hydrocarbon receptor and it is of two kinds of organic compounds whose structure and properties are analogous or isomers. Dioxins can enhance the pathogenic role of estrogen and reduce the inhibitory effect of progesterone in EMs. It can promote the serection of regulated on activation, normal T-cell expressed and secreted （Rantes）, matrix metalloproteinase-2 （MMP-2） and tumor necrosis factor-α （TNF-α）. Many laboratory and population-based studies suggest that exposure to environmental toxicants may be one of several etiologies of EMs.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2015年第11期806-810,共5页
Reproduction and Contraception
