摘要
目的 探讨血清维生素D水平与妊娠期糖尿病的相关性。方法 选择2013年12月~2015年3月贵州医科大学附属医院180例孕妇为研究对象,所有孕妇均于孕11~13＋6周进行维生素D水平的检测,随访至孕24~28＋6周所有患者均进行口服葡萄糖耐量试验（OGTT）检测。统计分析所有孕妇的维生素D及空腹血糖水平,采用Pearson相关系数分析孕期维生素D水平与妊娠期期糖尿病的相关性。结果 180例孕妇中,妊娠期糖尿病患者78例（43.33%）,非妊娠期糖尿病患者102例（56.67%）;维生素D缺乏者44例（24.44%）,维生素D不足者42例（23.33%）,维生素D充足者94例（52.22%）。妊娠期糖尿病患者维生素D水平[（17.9±4.2）ng/m L]明显低于非妊娠期糖尿病患者[（35.3±6.4）ng/m L],差异有统计学意义（P〈0.05）。其中妊娠期糖尿病患者维生素D缺乏者及维生素D不足者所占比例（52.56%、41.03%）均明显高于非妊娠期糖尿病患者（2.94%、9.80%）,而维生素D充足者所占比例（6.41%）明显低于非妊娠期糖尿病患者（87.26%）,差异有高度统计学意义（P〈0.01）。Pearson相关性分析结果显示,孕妇维生素D水平与其空腹血糖水平呈显著负相关（r=-0.692,P〈0.05）。结论 妊娠期糖尿病发病率较高,且妊娠期糖尿病患者的维生素D水平明显低于非妊娠期糖尿病患者,孕妇维生素D水平与其血糖水平呈显著负相关,临床上可通过调节维生素D水平对妊娠期糖尿病的发病或血糖水平进行干预。
Objective To explore the correlation between vitamin D levels and gestational diabetes. Methods 180 cases of pregnant women from December 2013 to March 2015 in the Affiliated Hospital of Guiyang Medical College were se- lected as the research objects, the vitamin D levels of all pregnant women were tested at 11-13＋6 weeks of pregnancy, follow-up to 24-28＋6 weeks, all pregnant women were given the OGTr test, levels of vitamin D and fasting blood glu- cose （FBG） were analyzed statistically, and the correlation between vitamin D levels and diabetes during pregnancy was analyzed by Pearson coefficient analysis. Results Of 180 cases of pregnant women, there were 78 cases （43.33%） of gestational diabetes meIIitus, 102 cases （56.67%） without gestational diabetes mellitus, and 44 cases （24.44%） of vita- min D deficiency, 42 cases （23.33%） of vitamin D deficiencies, 94 cases （52.22%） of adequate vitamin D. Vitamin D levels of the patients with gestational diabetes mellitus [（17.9±4.2） ng/mL] was significantly lower than that of the patients without gestational diabetes mellitus [（35.3±6.4） ng/mL], the difference was statistically significant （P 〈 0.05）. The proportion of patients with gestational diabetes mellitus and deficiency and insufficiency of Vitamin D （52.56%, 41.03%） were significantly higher than those without gestational diabetes mellitus （2.94%, 9.80%）, while proportion of patients with adequate vitamin D （6.41%） was significantly lower than that without gestational diabetes mellitus （87.26%）, the differences were statistically significant （P 〈 0.01）. Pearson correlation analysis results showed that, levels of vitamin D of pregnant women was significantly negative correlated with the levels of FBG （r=-0.692, P 〈 0.05）. Conclusion High prevalence of gestational diabetes, and gestational diabetes mellitus patient＇s levels of vitamin D is significantly lower than the patients without gestational diabetes mellitus, pregnant women levels of vitamin D is significantly negatively related with blood sugar levels, and the incidence of gestational diabetes mellitus and FBG levels can be intervened by regulation of vitamin D levels clinically.
出处
《中国医药导报》
CAS
2015年第33期121-124,共4页
China Medical Herald
基金
贵州省科技厅联合基金项目(TN2014-55)
关键词
维生素D
妊娠期糖尿病
相关性
Vitamin D
Gestational diabetes mellitus
Correlation
