摘要
目的探讨手足口病患儿的细胞免疫功能水平与患儿病情严重程度的关系。方法选择我院在2014年1月至2015年1月期间收治的312例手足口病患儿作为研究对象,按照患儿病情分为轻症组(n=134)、重症组(n=178),并选择同期来我院健康体检的150儿童作为对照组,采用流式细胞仪检测T细胞亚群百分率。结果重症组患儿的CD3、CD4、CD8均明显低于轻症组、对照组,均P<0.05,差异具有统计学意义;轻症组患儿的CD3、CD4、CD8明显低于对照组,均P<0.05,差异具有统计学意义;轻症组、重症组患儿的CD4/CD8明显低于对照组,P<0.05,差异具有统计学意义;轻症组患儿NK细胞为0.14±0.06、B淋巴细胞为0.15±0.07,重症组患儿NK细胞为0.15±0.07、B淋巴细胞为0.17±0.08,对照组儿童NK细胞为0.13±0.06、B淋巴细胞为0.15±0.06,三组受试者的NK细胞、B淋巴细胞检测值均无显著性差异(P>0.05)。结论因肠道病毒71型(EV71)感染手足口病患儿细胞免疫功能降低可能是导致手足口病病情加重的原因,通过及时了解患儿的细胞免疫功能变化对及早干预并治疗重症手足口病具有积极影响。
Objective To investigate the relationship between the cellular immune function levels of children with hand-foot-mouth disease （HFMD） and the severity of children＆#39;s disease. Methods 312 cases of children with HFMD in our hospital from January 2014 to January 2015 were selected as research objects, and divided into mild group （n=134） and severe group （n=178） according to the severity of disease. 150 healthy children at the same period were selected as control group. The percentage of T cell subsets was detected by flow cytometry. Results The levels of CD3, CD4 and CD8 of the severe group were significantly lower than those of the mild group and the control group, with statistically significant difference （P〈0.05）. The levels of CD3, CD4 and CD8 of the mild group were significantly lower than those of the control group, with statistically significant difference （P〈0.05）. The CD4/CD8 of the mild group and severe group were significantly lower than that of the control group, with statistically significant difference （P〈0.05）. NK cell and B lymphocytes were 0.14 ± 0.06 and 0.15 ± 0.07 of the mild group respectively, 0.15 ± 0.07 and 0.17 ± 0.08 of the severe group respectively, and 0.13 ± 0.06 and 0.15 ± 0.06 of the control group respectively;No statistical difference was found among three groups in NK cells and B lymphocytes （P ＆gt;0.05）. Conclusions The infection of enterovirus 71 （EV71） may lead to HFMD children＆#39;s lower cellular immune function, which may probably cause the severity of HFMD. It may have a positive impact on early intervention and treatment of severe hand-foot-mouth disease to learn about changes in children＇s cellular immune function timely.
出处
《临床医学工程》
2015年第11期1432-1433,共2页
Clinical Medicine & Engineering
基金
湖南省卫计委课题(项目编号:B2015-131)
关键词
重症手足口病
细胞免疫功能
T细胞亚群
Severe hand-foot-mouth disease
Cellular immunity function
T cell subsets
