摘要
目的 观察中剂量丙种球蛋白治疗特发性血小板减少性紫癜 (ITP)的近期疗效。方法 将确诊的 74例ITP患者 ,随机分为中剂量丙种球蛋白治疗组 39例 ,丙种球蛋白 0 .2g·kg·d-1,iv ,连续给药 4d ,治疗完成后用肾上腺皮质激素维持 ;大剂量丙种球蛋白为对照组 35例 ,丙种球蛋白 0 .4g·kg·d-1,iv ,连续给药 4d ,维持药物同治疗组。结果 治疗组 39例 ,显效 17例 ,总有效率 92 .31% ;对照组 35例 ,显效 16例 ,总有效率 94 .2 8%。两组比较无显著差异 (P >0 .0 5 ) ,治疗组未发现不良反应。结论 中剂量丙种球蛋白对ITP的近期治疗 ,疗效确切 ,无不良反应 ,且降低费用。
Aim To study the effects of average dosage γ grobulin in the treatment of Recucish Purpura of Specific Blood Platelet.Methods ITP paients(n=39)were treated with average dosage γ globulin(0.2g·kg·d -1 ) 4d in therapeutic group.Whereafter,it was maintained withadrenal gland.In control group(n=35),the ITP paients were treated with γ-globulin 0.4g·kg·d -1 and maintained with the same as that of the therapeutic group.Results In therapeutic group,very effective results were obstained in 17paients,striking improvement in 19,ineffective in 3,with a total efficacy rate of 92.31%;In control group,very effective results were obstained in 16,striking improvement in 17,ineffective in 2 paient,with a total efficacy rate of 94.28%.There was not obvious differences between the two groups and adverse reaction was not found during administration Conclusion Average dosage γ globulin has striking therapeutic effect in ITP.It is a safe and effective drug and not easy to make the disease reoccur.
出处
《解放军药学学报》
CAS
2002年第4期243-244,共2页
Pharmaceutical Journal of Chinese People's Liberation Army
