摘要
目的:探讨骨瓜提取物注射液对类风湿关节炎临床症状及实验室指标的影响。方法:选择活动期类风湿关节炎患者116例,采用随机数字表法分为治疗组和对照组,每组58例。对照组给予甲氨蝶呤、来氟米特、醋酸泼尼松、双氯芬酸钠缓释片口服治疗,治疗组在对照组治疗基础上联合骨瓜提取物注射液静滴治疗。两组均以3周为1个疗程。观察两组患者临床疗效、临床症状、实验室指标、药物不良反应。结果:治疗组明显进步6例,进步21例,改善22例,无效9例,总有效率为84.48%;对照组明显进步3例,进步19例,改善18例,无效18例,总有效率为68.97%。两组比较,差异有统计学意义(P<0.05)。治疗后,两组晨僵时间、关节肿痛指数、关节压痛指数及实验室指标均有改善(P<0.05),且治疗组优于对照组(P<0.05);两组患者药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论:骨瓜提取物注射液有助于缓解类风湿关节炎炎症状态,改善临床症状,提高治疗效果。
Objective：To investigate the effect of Gugua Extractives Inject on clinical symptoms and laboratory indexes of rheumatoid arthritis.Methods：116 patients with active rheumatoid arthritis were randomly divided into a treatment group and a control group,58 cases in each group.The control group was orally given me thotrexate,leflunomide,prednisone acetate,and diclofenac sodium sustained-release tablets,while the treatment group was given intravenous drip of Gugua Extractives Inject based on the treatment of the control group.Both groups were treated for 3 weeks,observing their clinical efficacy, clinical symptoms,laboratory indexes,and adverse drug reactions.Results：In the treatment group,6 cases were excellent,21 cases were obviously improved,22 cases were improved,and 9 cases were ineffective,the total effective rate being 84.48%;while in the control group, 3 cases were excellent, 19 cases were obviously improved,18 cases were improved,and 18 cases were ineffective,the total effective rate being 68.97%.The difference between the two groups was statistically significant （ P 〈 0.05 ） .After treatment,the morning stiffness,joint pain index,joint pain tenderness index and laboratory index of the two groups were improved （ P 〈 0.05 ） ,and the treatment group was better than the control group （ P 〈 0.05 ）.The incidence of adverse drug reactions in the two groups was not statistically significant （ P 〉 0.05 ）. Conclusion：Gugua Extractives Inject can relieve rheumatoid arthritis,improve clinical symptoms,and enhance the treatment effect.
出处
《风湿病与关节炎》
2015年第11期16-19,共4页
Rheumatism and Arthritis
关键词
关节炎
类风湿
骨瓜提取物
临床症状
实验室指标
arthritis,rheumatoid
Gugua Extractives Inject
clinical symptom
laboratory index
