摘要
目的:探讨米索前列醇不同给药方式联合宫腔吸引管在剖宫产术后无痛人流中的应用。方法:214例剖宫产术后无痛人流患者随机分为A组(71例)、B组(71例)、C组(72例)。所有患者均给予常规静脉麻醉后,A组患者术前2 h给予米索前列醇0.6mg,口服;B组患者术前3 h给予米索前列醇片0.2 mg,研粉后置入阴道后穹窿;C组患者不给予相关药物。各组患者均使用一次性宫腔吸引管。观察各组患者的镇静效果、宫颈扩张效果、手术时间、术中出血量、苏醒时间、异丙酚用量、并发症发生情况及不良反应发生情况。结果:A组患者手术时间、术中出血量<B组<C组,差异有统计学意义(P>0.05),A组患者苏醒时间、异丙酚用量<B、C组,差异均有统计学意义(P<0.05),但B、C两组间比较差异无统计学意义(P>0.05);A、B组患者镇静、宫颈扩张总有效率显著高于C组,差异有统计学意义(P<0.05),但A、B两组间比较差异无统计学意义(P>0.05);A组患者并发症发生率<B组<C组,差异有统计学意义(P<0.05)。各组患者不良反应发生率比较,差异无统计学意义(P>0.05);结论 :口服或阴道给予米索前列醇联合宫腔吸引管治疗剖宫产术后无痛人流的疗效和安全性均相当,但口服给药可减少麻醉药物用量,减少术中出血量,缩短手术时间。
OBJECTIVE：To study the adhibition of misoprostol combined with palace cavity attraction tube in the treatment of painless abortion after cesarean section. METHODS：214 patients who received painless abortion after cesarean section were randomly divided into group A（71 case）,group B（71 case）and group C（72 case）. After all patients were given conventional intravenous anesthesia,Group A was given misoprostol 0.6 mg for oral administration in preoperative 2 h. Group B was given Misoprostol tablet 0.2 mg abrasive powder put in posterior fornix in preoperative 3 h. Group C did not give any drugs. All the groups used disposable suction curettage tube. The efficacies of sedation and cervical dilatation,operation time,intraoperative blood loss,recovery time,dosage of propofol and incidences of complications and adverse reactions in the 3 groups were observed. RESULTS：The operation time,intraoperative blood loss in group A were lower than group B and lower than group C,the differences were statistically significant（P〈0.05）;recovery time and dosage of propofol in group A were lower than group B and C,the differences were statistically significant（P〈0.05）,howerer,there was no significant difference between group B and C（P〉0.05）. The total effective rates of sedation and cervical dilatation in group A and B were significantly higher than group C,and the difference was statistically significant（P〈0.05）,however,there was no significant difference between group A and B（P〉0.05）. The incidence of complications in group A was lower than group B and lower than group C,and the difference was statistically significant（P〈0.05）.There was no significant difference in the incidence of adverse reactions among 3 groups（P〉0.05）. CONCLUSIONS：The efficiency and safety of misoprostol for oral administration or medicated vaginal suppository combined with palace cavity attraction tube in the treatment of painless abortion after cesarean section is similar,but oral administration can reduce the dosage of anesthetics,operation time and smaller intraoperative blood loss volume.
出处
《中国药房》
CAS
北大核心
2015年第33期4631-4633,共3页
China Pharmacy
关键词
米索前列醇
无痛人流
宫腔吸引管
剖宫产
Misoprostol
Painless abortion
Palace cavity attraction tube
Cesarean section
