摘要
目的比较肺表面活性物质治疗内源性与外源性新生儿急性肺损伤(ALI)的临床疗效。方法选取2014年1月—2015年1月衡水市第二人民医院收治的60例新生儿ALI患儿,根据病因分为内源组和外源组,每组30例。两组患儿均采用常规治疗,并联合机械通气与肺表面活性物质治疗。比较两组患儿治疗前及治疗2 h、24 h、48 h和拔管前肺顺应性、氧合指数,记录并比较两组患儿住院时间、机械通气时间和病死率。结果外源组患儿治疗前,治疗2 h、24 h、48 h及拔管前肺顺应性均高于内源组(P<0.05)。两组患儿治疗前及拔管前氧合指数比较,差异无统计学意义(P>0.05);外源组患儿治疗2 h、24 h、48 h氧合指数低于内源组(P<0.05)。外源组患儿住院时间及机械通气时间均短于内源组,病死率低于内源组(P<0.05)。结论较之内源性新生儿ALI,肺表面活性物质对外源性新生儿ALI的治疗效果更好,肺顺应性及氧合指数的改善效果更佳,更有利于缩短住院时间、机械通气时间。
Objective To compare the clinical effect of pulmonary surfactant on endogenous and exogenous neonatal acute lung injury. Methods A total of 60 newborns with neonatal acute lung injury were selected in the Second People＇ s Hospital of Hengshui from January 2014 to January 2015,and they were divided into A group（ with endogenous neonatal acute lung injury） and B group（ with exogenous neonatal acute lung injury） according to the etiological factor, each of 30 cases. Newborns of both groups received conventional treatment, mechanical ventilation and pulmonary surfactant. Lung compliance and oxygenation index before treatment,after 2 hours,24 hours and 48 hours of treatment,and before extubation were compared between the two groups,hospital stays,mechanical ventilation time and mortality were recorded. Results Lung compliance of B group was statistically significantly higher than that of A group at the time point before treatment,after 2 hours,24 hours,48 hours of treatment, before extubation, respectively（ P〈0. 05）. No statistically significant differences of oxygenation index was found between the two group at the time point before treatment or before extubation（ P〈0. 05）,while oxygenation index of B group was statistically significantly lower than that of A group at the time point after 2 hours,24 hours,48 hours of treatment, respectively（ P〈0. 05）. Hospital stays and mechanical ventilation time of B group were statistically significantly shorter than those of A group,and mortality of B group was statistically significantly lower than that of A group（ P〈0. 05）. Conclusion Compared with endogenous neonatal acute lung injury,pulmonary surfactant has better clinical effect in treating exogenous neonatal acute lung injury,has better improvement effect on lung compliance and oxygenation index,is more helpful to shorten the hospital stays and mechanical ventilation time.
出处
《实用心脑肺血管病杂志》
2015年第9期51-53,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
急性肺损伤
肺表面活性剂
婴儿
新生
疗效比较研究
Acute lung injury
Pulmonary surfactants
Infant
newborn
Comparative effectiveness research
