摘要
目的 研究尼莫地平对短暂性脑缺血发作（TIA）后认知功能及血液流变学指标的影响。方法 以我院2010年1月~2013年1月收治的60例TIA患者为研究对象,随机双盲法将其分为两组,各30例。对照组采取常规治疗,观察组在对照组基础上联合尼莫地平治疗,比较两组治疗前后血液流变学指标及简明精神状态量表（MMSE）评分。结果观察组治疗后MMSE评分为（27.00±2.32）分,低于对照组的（18.68±4.56）分,差异有统计学意义（P〈0.05）。观察组治疗后血浆黏度、全血黏度高切、全血黏度低切、纤维蛋白原及血小板聚集度均明显低于对照组,差异有统计学意义（P〈0.05）。结论 尼莫地平能明显改善TIA患者血液流变学指标,显著促进患者认知功能障碍的改善,值得临床推广。
Objective To study the effect of Nimodipine on the cognitive function and hemorheology indexes after tran- sient ischemic attack. Methods 60 patients with transient ischemic attack admitted into the hospital from January 2010 to January 2013 were selected as the research object and were divided into two groups by randomly double blind method with 30 cases in each.The control group received routine treatment while the observation group received com- bined Nimodipine treatment based on the treatment of the control group.The changes of hemorheology indexes and MMSE scores before and after the treatment were compared between the two groups. Results MMSE score of the obser- vation group after the treatment was （27.00＋2.32） scores,compared with （18.68＋_4.56） scores of the control group,the difference was statistically significant （P 〈 0.05）.The plasma viscosity,whole blood viscosity at both high and low shear, fibrinogen and the degree of platelet aggregation of the observation group after the treatment were significantly lower than those of the control group and the differences were statistically significant （P 〈 0.05）. Conclusion Nimodipine can significantly improve the hemorheology indexes in patients with transient isehemic attack and alleviate the cognitive im- pairment in patients which is worthy of promotion.
出处
《中国当代医药》
2015年第31期133-135,共3页
China Modern Medicine
