摘要
目的观察放疗联合紫杉醇与卡铂同步化疗对中晚期宫颈癌的临床效果及安全性。方法选择2009年1月至2013年12月在湖南省肿瘤医院进行治疗的中晚期宫颈癌患者46例为观察组,患者均接受放疗联合紫杉醇、卡铂同步化疗。根据病例对照的原则,选择年龄、卡氏评分等与观察组资料均衡的、行单纯放疗的宫颈癌患者46例为对照组。对比两组的临床效果及安全性。结果观察组患者近期疗效显著优于对照组,差异有统计学意义(P<0.05);观察组发生骨髓抑制、胃肠道反应程度重于对照组(P均<0.05);两组放射性肠炎、膀胱炎发生率差异无统计学意义(P>0.05)。观察组患者5年生存率高于对照组(P<0.05),局部复发率和远处转移率低于对照组(P均<0.05)。结论放疗联合紫杉醇、卡铂同步化疗治疗中晚期宫颈癌效果显著,患者耐受性好,不良反应程度较轻。
Objective To study the clinical efficacy and safety of radiotherapy combined with paclitaxel and carboplatin chemotherapy on the patients with metaphase or advanced cervical cancer. Methods 46 cases of patients with advanced cervical cancer were chosen as the observation group. Patients all received radiotherapy combined with paclitaxel and carboplatin chemotherapy. According to the case control principle,46 cases of cervical cancer were selected as the control group. The clinical efficacy and safety were compared after treatment. Results The curative effect of observation group was significantly better than that of the control group（P〈0.05）. The marrow suppression and gastrointestinal reaction in observation group were more serious than that in the control group（P〈0.05）. The incidence of radiation enteritis and radiation cystitis are no significant difference between the two groups（P〈0.05）. The 5-years survival rate of the observation group was higher than that of the control group（P〈0.05）. The local recurrence rate was lower than that of the control group（P〈0.05）.The rate of distant metastasis was lower than that of control group（P〈0.05）. Conclusion Radiotherapy combined with paclitaxel and carboplatin chemotherapy in the treatment of advanced cervical cancer effect is remarkable. The patients could tolerate and the incidence of adverse reaction decreased obviously.
出处
《热带医学杂志》
CAS
2015年第10期1359-1361,共3页
Journal of Tropical Medicine
关键词
宫颈癌
放疗
紫杉醇
卡铂
Cervical cancer
Radiotherapy
Paclitaxel
Carboplatin
