摘要
目的探讨血清同型半胱氨酸(Hcy)、成纤维细胞生长因子23(FGF-23)、klotho蛋白与血液透析患者心血管疾病的关系。方法选取2014年6月-2015年5月在本院进行维持性血液透析患者共85例为研究组,同时选择进行体检的85名健康人为对照组。研究组又分为心血管功能差组(n=29)与心血管功能正常组(n=56)。所有研究对象检测采血检测空腹血糖(FPG)、血红蛋白(Hb)、白蛋白(ALB)、肌酐(Cr)、尿素氮(BUN)、尿酸(UA)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、FGF-23、Hcy和klotho蛋白水平,并比较分析。结果研究组血清ALB、Hb、HDL和Klotho蛋白含量的水平低于对照组,Cr、BUN、UA、FGF23和Hcy水平高于对照组,差异均有显著性(P<0.05),两组的FPG、TC、TG和LDL的含量无显著差异(P>0.05)。心血管功能差组的FGF23、Hcy含量显著高于心血管功能正常组,Klotho蛋白显著低于心血管功能正常组。结论 Hcy、FGF 23和klotho蛋白与维持性血液透析患者心血管病变有着密切的联系。
Objective To investigate the relationship between Hcy,FGF23,klotho and cardiovascular disease in hemodialysis patients. Methods 85 patients with maintenance hemodialysis in our hospital from June 2014 to May 2015 were selected as study group, and 85 healthy personnel at the same time were selected as control group. The study group was divided into cardiovascular disease group（n = 29） and non-cardiovascular disease group （n= 56）. Serum levels of fasting plasma glucose（FPG）, blood hemoglobin（Hb）, alburnin（ALB）, creatinine（Cr）, blood urea nitrogen（BUN）, uric acid （ UA）, triglycerides （ TG）, total cholesterol （ TC）, high density lipoprotein cholesterol （ HDL）, low density lipoprotein cholesterol（LDL）,.FGF-23,Hcy and klotho were detected in all of the subjects, and comparative analysis was undertaken. Results Serum levels of Cr, BUN, UA, FGF23 and Hcy were significantly higher than the control group （all P〈0.05）;FPG, Hb,ALB, HDL and klotho in the study group were significantly lower than the control group; FPG.TC.TG and LDL had no significant differences in two groups（all P〉0.05）. FGF23 and Hcy in cardiovascular disease group was significantly higher than non cardiovascular disease group, and Klotho was significantly lower than non-cardiovascular disease group. Conclusion Hcy,FGF 23 and klotho are closely linked to cardiovascular disease in patients with maintenance hemodialysis.
出处
《中国实验诊断学》
2015年第11期1856-1859,共4页
Chinese Journal of Laboratory Diagnosis
