摘要
目的:观察补肾蠲痹汤联合小剂量甲氨蝶呤治疗老年类风湿关节炎患者的临床疗效。方法:将82例患者分为治疗组和对照组,每组41例。对照组单纯采用甲氨蝶呤治疗,治疗组在对照组治疗基础上加服补肾蠲痹汤治疗,每天1剂。两组均治疗4个月。记录治疗前后关节肿胀指数、关节疼痛指数、双手握力、晨僵时间变化情况,检测治疗前后血沉、C反应蛋白、类风湿因子等,并记录两组患者不良反应。结果:治疗组临床有效率为95.11%,对照组有效率为80.48%,两组比较,差异有统计学意义(P<0.05);治疗后两组患者的关节肿胀指数、关节疼痛指数、晨僵时间、双手握力较治疗前改善,治疗组优于对照组,差异有统计学意义(P<0.01);治疗后两组血沉、C反应蛋白和类风湿因子水平均较治疗前降低,治疗组治疗后血沉、C反应蛋白和类风湿因子水平均低于对照组,差异有统计学意义(P<0.01);治疗组不良反应发生率为17.07%,对照组不良反应发生率为65.85%,两组比较,差异有统计学意义(P<0.01)。结论:补肾蠲痹汤联合小剂量甲氨蝶呤治疗老年类风湿关节炎患者能提高临床疗效,减少不良反应的发生。
Objective： To observe the clinical curative effect of Bushenjuanbi soup combined with small dose methotrexate in treating elderly rheumatoid arthritis. Methods： 82 patients were divided into treatment group and control group,41 cases of each group. The control group was given Methotrexate treatment and the treatment group was given additional Bushenjuanbi soup,1 agent daily. Two groups were treated for four months. Recorded the joint swelling,joint pain index,hands grip strength,morning stiffness before and after the treatment. Detect the blood sedimentation,c-reactive protein,rheumatoid factor before and after treatment and record adverse reactions in both groups. Results： The clinical effective rate was 95. 11% in treatment group and 80. 48% in control group. Compared of the two groups,the difference was statistically significant（ P〈0. 05）. The joint swelling index,the index of joint pain,morning stiffness time,hands grip strength of two groups were improved compared with before the treatment（ P〈0. 01）. The treatment group was better than that of control group. The difference was statistically significant（ P〈0. 01）. The blood sedimentation after treatment,c-reactive protein and rheumatoid factor levels of two groups were reduced. The blood sedimentation after treatment,c-reactive protein level and rheumatoid factor of treatment group were lower than that of control group（ P〈0. 01）; The total incidence of adverse reactions was 17. 07% in treatment group and 65. 85% in control group,the difference was statistically significant（ P〈0. 01）. Conclusion： Bushenjuanbi soup combined with small dose methotrexate in treating elderly rheumatoid arthritis can improve clinical curative effect and reduce the occurrence of adverse reactions.
出处
《中医学报》
CAS
2015年第11期1661-1663,共3页
Acta Chinese Medicine
基金
湖北省中医药管理局科技计划项目(2014A1013)
