摘要
目的探讨新乡地区脑性瘫痪（脑瘫）儿童的母亲孕期及新生儿期危险因素。方法回顾性分析新乡地区脑瘫儿童问卷调查资料。研究对象为出生日期在2005年5月1日至2010年4月30日的脑瘫儿童。同时选取与脑瘫患儿匹配的3例健康儿童设为健康对照组。分析本地区儿童脑瘫的相关危险因素。结果新乡地区脑瘫儿童孕期及新生儿期高危因素：孕期相关因素有母亲营养状态、孕期阴道出血、妊娠高血压病、异常产史（χ^2=2．313、13．296、5．034、7．434，P均〈0．05）；新生儿期相关因素有早产、重度窒息、重度黄疸、颅内感染（χ^2=4．637、29．50、4．633、5．107，P均〈0．05）。多因素Logistic回归分析显示出生重度窒息（OR=2．340，95％CI：1．250～4．440）、重度黄疸（OR=4．11，95％CI：2．430～6．740）、早产（OR=2．570，95％CI：1．410～4．770）、妊娠高血压病（OR=2．350、95％CI：1．020～5．440）、孕期阴道出血（OR=73．600，95％CI：3．060～17．750）、异常产史（OR=5．710，95％CI：1．250～26．310）为儿童脑瘫的独立危险因素。结论重度窒息、重度黄疸、早产、妊娠高血压病、孕期阴道出血、异常产史为新乡地区儿童脑瘫的独立危险因素。应积极加强对易导致脑瘫的高危新生婴儿的筛查及规范管理，做好围生期高危孕妇管理。早期预防有助于减少本地区脑瘫的发生。
Objective To explore the risk factors of children with cerebral palsy during pregnancy and neonatal period in Xinxiang area. Methods A retrospective analysis of the relevant research data of cerebral palsy children in Xinxiang area was performed. The research objects were children with cerebral palsy born from May 1,2005 to April 30,2010. At the same time,3 healthy children were selected as the control group to analyze the related risk factors causing cerebral palsy in children. Results The risk factors of children with cerebral palsy in Xinxiang city were as follows ： maternal nutritional status, vaginal bleeding during pregnancy, pregnancy - induced hypertension syndrome, and abnormal production history were associated with cerebral palsy（χ^2 = 2.313,13. 296,5. 034,7. 434, all P 〈 0.05） during the perinatal period;related factors during neonatal period were premature birth, severe asphyxia, severe jaundice, and intraeranial infection（χ^2 = 4. 637,29.50,4. 633,5. 107, all P 〈 0.05 ）. Multivariate Logistic regression analysis showed the history of severe asphyxia （ OR = 2. 340,95 % CI： 1. 250 - 4. 440）, severe jaundice （ OR = 4.110, 95 % CI：2. 430 - 6. 740） , premature birth （ OR = 2. 570,95 % CI： 1. 410 - 4. 770 ） , pregnancy - induced hypertension syndrome （ OR = 2. 350,95 % CI： 1. 020 - 5. 440 ） , vagina] bleeding during pregnancy （ OR = 73. 600,95 % CI： 3. 060 - 17. 750） and abnormal production history（ OR =5. 710,95% CI：1. 250 -26. 310） were independent risk factors causing children with cerebral palsy. Conclusions The history of severe asphyxia, severe jaundice, premature birth, pregnancy- induced hypertension syndrome, vaginal bleeding during pregnancy and congenital dysplasia are independent risk factors of children with cerebral palsy in Xinxiang area. It should be strengthened to screen and standardize the management of high - risk newborn infants with cerebral palsy, and do well management for perinatal high - risk pregnant women management. Early prevention can help to reduce the incidences of cerebral palsy in local area.
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2015年第22期1735-1737,共3页
Chinese Journal of Applied Clinical Pediatrics
关键词
新乡地区
脑性瘫痪
危险因素
孕期
新生儿期
Xinxiang area
Cerebral palsy
Risk factor
Pregnancy
Neonatal period
