摘要
目的 :探讨葛根总黄酮缓释片的体外释放度及其释药动力学 ,测定、比较生物粘附性缓释片和普通片与家兔离体胃、小肠组织的粘附力。方法 :采用转篮法 ,以0 1mol/LHCl900ml为溶出介质 ,转速100r/min测定其累积释放度 ,并分别用单指数模型、威布尔分布函数、Higuchi方程、零级释放模型对释放度进行释药动力学模拟 ,根据各模型拟合的AIC计算值与实测值的绝对误差和相对误差确定缓释片的最佳拟合模型 ,同时以自制粘附力测定装置测定、比较生物粘附性缓释片及普通片与家兔离体胃、肠组织的粘附力。结果 :缓释片以单指数模型拟合最佳 ,生物粘附性缓释片与家兔离体胃、肠组织的粘附力明显大于普通片 (P<0 01) ,且与小肠的粘附力大于胃 (P<0 05)。结论 :缓释片在体外释药动力学符合单指数模型 ;生物粘附性缓释片在胃、肠道具有较强的粘附作用。
OBJECTIVE:To study the dissolution rate of total puerariae flavones(TPF)bioadhesive sustained-release tablet,and to determine its bioadhesive force to animal stomach and small intestine in vitro METHODS:Using rotating basket method,the dissolubility summation was determined with 0 1mol/L HCl as dissolution medium at speed of 100r/min,single-index model,Weibull distributing model,Higuchi equation and zero-class model were used to imitate the dissolution curve The biggest absolute error,the biggest relative error and AIC were used as comprehensive indices to select the best imitating model A new apparatus made by ourselves was used to compare the adhesive force between the sustained-release tablets and popular tablets in adhering to rabbits'stomach or small intestine RESULTS:The results showed that the dissolution rate in vitro imitated in single-index model was the best Bioadhesion study showed that there were obvious differences between bioadhesive sustained-release tablets and non-bioadhesive tablets in adhering with gastric mucosa and small intestines mucosa(P<0 01),and the bioadhesion to small intestines mucosa was stronger than to gastric mucosa(P<0 05) CONCLUSIONS:The dissolution rate in vitro of the sustained-release tablets conforms to single-index model The adhesive force of TPF bioadhesive sustained-release tablets is stronger than that of non-bioadhesive tablets
出处
《中国药房》
CAS
CSCD
2002年第8期459-461,共3页
China Pharmacy
基金
湖南省科技厅资助项目 (1012-28)
关键词
葛根总黄酮
生物粘附性缓释片
释放度
组织粘附力
total puerariae flavones
bioadhesive sustained-release tablet
dissolution rate
bioadhesion
