摘要
目的评价血清可溶性凝集素样氧化型低密度脂蛋白受体-1(s LOX-1)的水平是否与患者存在代谢综合征及冠心病相关。方法该横断面研究共纳入278例患者,分为四组:无代谢综合征和冠心病组(Met S-/CAD-,n=76),有代谢综合征无冠心病组(Met S+/CAD-,n=42),有冠心病无代谢综合征组(Met S-/CAD+,n=89),有代谢综合征和冠心病组(Met S+/CAD+,n=71)。用酶联免疫吸附法(ELISA)测量每组研究对象的s LOX-1水平。结果患者血清s LOX-1水平Met S+/CAD-组及Met S-/CAD+与Met S-/CAD-组相比,均明显升高(P<0.01),而Met S+/CAD+组血清s LOX-1水平较Met S+/CAD-组及Met S-/CAD+也明显升高(P<0.01)。多元Logistic回归结果显示血清s LOX-1水平与代谢综合征和冠心病均呈独立相关(P<0.01)。结论血清s LOX-1水平与患者患代谢综合征及冠心病独立相关,血清s LOX-1可能是对代谢综合征和冠心病进行早期诊断和风险评估的重要因子。
Objective To investigate the relationship of circulating soluble lectin-like oxidized low-density lipoprotein receptor-1（ s LOX-1） levels with the metabolic syndrome and coronary artery diseases. Methods A total of 200 patients were enrolled in this cross-sectional study. Patients were classified as no metabolic syndrome / no coronary artery disease group（ Met S-/ CAD-,n =76）,Met S＋/ CADgroup（ n = 42）,Met S-/ CAD＋group（ n = 89）,Met S＋/ CAD＋group（ n = 71）. Results The serum s LOX-1 levels were significantly higher in Met S＋/ CAD＋,Met S＋/ CAD-and Met S-/ CAD＋groups than in Met S-/ CAD-group（ P 0. 01 for all comparisons）,and it was significantly higher in Met S＋/ CAD＋group than in Met S＋/ CAD＋group and Met S＋/ CAD-group（ P 0. 01 for all comparisons）.Multivariate Logistic regression demonstrated that serum s LOX-1 level was independently associated with the presence of metabolic syndrome（ P 0. 01） and CAD（ P 0. 01）. Conclusion Serum s LOX-1 level is independently associated with the presence of metabolic syndrome and CAD,and it may be an important factor in early diagnosis and risk evaluation of metabolic syndrome and CAD.
出处
《山西医科大学学报》
CAS
2015年第11期1065-1067,共3页
Journal of Shanxi Medical University
