期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

钙卫蛋白在类风湿关节炎患者病情判断中的意义

下载PDF
导出
摘要 类风湿关节炎（RA）是常见的以关节滑膜慢性炎症病变为主要表现的自身免疫病,逐渐出现不可逆性骨关节破坏,从而造成运动功能的丧失和生活质量的下降。早期运用免疫抑制剂治疗能控制病情进展,阻止关节破坏,防止关节功能丧失[1]。钙卫蛋白（Cal）是一种来源于中性粒细胞和巨噬细胞的含钙蛋白,其表达具有组织或细胞特异性,可作为急性炎性细胞活化的标志物,同时也可用于自身免疫性疾病的检测[2]。因此,
作者 李泽亮 于代友 陈雯 何寿华
机构地区 河北省沧州中西医结合医院放射科
出处 《山西医药杂志》 CAS 2015年第22期2693-2694,共2页 Shanxi Medical Journal
关键词 类风湿关节炎 骨关节破坏 自身免疫病 关节滑膜 细胞特异性 慢性炎症病变 不可逆性 性细胞 急性炎 巨噬细胞
分类号 R593.22 [医药卫生—内科学]
  • 相关文献

参考文献12

  • 1American college of rheumatology subcommittee on rheuma- toid arthritis guidelines. Guidelines for the management of rheumatoid arthritis: 2002 Update [J]. Arthritis Rheum,2002,46(2):328-346.
  • 2李刚,李玉林.钙卫蛋白与临床疾病的关系[J].实用医学杂志,2007,23(15):2437-2439. 被引量：6
  • 3杨春兰,沈荣春,任小娟,陈建平,鞠少卿.4项指标联合检测对类风湿性关节炎的诊断价值[J].检验医学与临床,2013,10(20):2700-2701. 被引量：4
  • 4高丽霞.几种自身抗体检测对类风湿性关节炎的意义[J].国外医学（临床生物化学与检验学分册）,2002,23(2):79-80. 被引量：15
  • 5Fagerhol MK, Anderson T. Release and quantitation of a leucocyte derived protein[J]. Scand J Hcematd, 1980, 24 (6) :393-398.
  • 6刘文斌,吕愈敏,金珠,杨雪玲.钙卫蛋白在溃疡性结肠炎患者结肠黏膜及粪便中的表达及临床意义[J].北京大学学报（医学版）,2005,37(2):179-182. 被引量：16
  • 7Berntzen HB, Munthe E, Fagerhol MK. A longitudinal study of the leukocyte protein L1 as an indicator of disease activity in patients with rheumatoid arthritis[J]. J Rheumatol,1989, 16(11) : 1416-1420.
  • 8Berntzen HB, Fagerhol MK, Ostensen M, et al. The L1 protein as a new indicator of inflammatory activity in patients with juvenile rheumatoid arthritis[J]. J Rheumatol, 1991,18 (1): 133-138.
  • 9Kjeldsen-Kragh J, Mellbye OJ, Haugen M, et al. Changes in laboratory variables in rheumatoid arthritis patients during a trial of fasting and one-year vegetarian diet [J]. Scand J Rheumatol, 1995,24 (2) : 85-93.
  • 10Showji Y, Nozawa R, Sato K, et al. Seroprevalence of Heli- cobacter pylori infection in patients with connetive tissue dis- eases[J]. Microbiol Immunol,1996,40(7):499-503.

二级参考文献55

  • 1Schroder AE, Greinner A, Seyfert C, et al. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis[J]. Proc Natl Acad Sci USA, 1996,93: 221-225.
  • 2Masson-Bessiere C, Sebbag M, Durieux JJ et al. In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum[J]. Clin Exp Immunol, 2000,119 : 544-552.
  • 3Schellekens GA, De-Jong BAW, Van-Den-Hoogen FHJ,et al. Citrulline is an essential constitutent of antigenic determinants recognized by rheumatoid arhtritis specific autoantibodies[J]. J Clin Invest, 1998,101 : 273-281.
  • 4Girbal-Neuhauser E, Durieux JJ, Arnaud M et al. The epitopes targeted by the rheumatoid arthritis associated antifilaggrin autoantibodies are posttranslationally generated on various sites of(pro) filaggrin by deimination of arginine residues[J]. J Immunol, 1999,162: 585-594.
  • 5Carelle C, Reparon S, Wim JVE, et al. Secretion of anticitrulline containing peptide antibody by B lymphocytes in rheumaotid arhtritis [J]. Arthritis Rheu, 2001,44 ( 1 ) : 41-47.
  • 6Simon M, Girbal E, Sebba M et al. The cytokeratin Filament-aggregating protein filaggrin is the target of the socalled′ antikeratin antibodies′ autoantibodies specific for rheumatoid arthritis[J]. J Clin Invest 1993,92:1387-1393.
  • 7Hoet RM, Voorsmit RACA, Van-Venrooij WJ. The perinuclear factor, a rheumatoid arthritis specific autoantigen is not present in keratohyalin granules of cultured buccal mucosa cells[J]. Clin Exp Immunol, 1991,84: 59-65.
  • 8Menard HA, Lapointe E, Rahdi MD, et al. Insights into rheumatoid arthritis derived from the Sa immune system [J]. Arthritis Res, 2000,2(6) :429-432.
  • 9Hayem G, Chazerain P, Combe B, et al. Anti-Sa antibody is an accurate diagnostic and prognostic marker in adult arthritis[J]. J Rheumatol, 1999,26(9): 2069.
  • 10Steiner G, Slriner K, Hassfeld W, et al. Clinical and immunological aspects of autoantibodies to RA33/hn RNP-A/B protein a link between RA, SLE and MCTD[J]. Mol Biol Rep 1996,23(3-4) :167-171.

共引文献37

山西医药杂志
2015年 第22期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部