摘要
目的:观察自身免疫抗体甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶抗体(TPOAb)和促甲状腺素受体抗体(TRAb)在4种甲状腺疾病中的水平差异。方法:将2012年1月至2014年6月在佛山市中医院内分泌科门诊就诊的506例4种甲状腺疾病患者作为研究对象,定量检测患者血液中TGAb、TPOAb和TRAb抗体水平。结果:桥本甲状腺炎患者血液中TGAb和TPOAb值、阳性率最高,分别为1 439.0 IU/m L、87.7%和427.5 IU/m L、97.7%;Graves病患者血液中TRAb值和阳性率最高,为34.44 IU/L和100%;单纯性甲状腺肿及亚急性甲状腺炎患者血液中,甲状腺自身免疫抗体也有不同程度的升高。4种甲状腺疾病患者TGAb、TPOAb和TRAb抗体水平两两比较,除了亚急性甲状腺炎与桥本甲状腺炎患者的TRAb水平外,差异均有统计学意义(P<0.05)。结论:甲状腺自身免疫抗体TGAb、TPOAb和TRAb水平在不同甲状腺疾病中存在差异,结合分析对于甲状腺疾病尤其是自身免疫性甲状腺疾病具有重要的诊断价值。
Objective： To determine the different levels of the thyroid autoimmune antibodies,including thyroglobulin antibody（ TGAb） and antithyroid peroxidase antibody（ TPOAb） and thyroid stimulating hormone receptor antibody（ TRAb） in four kinds of thyroid diseases. Methods： A total of 506 patients with four kinds of thyroid diseases,who were hospitalized in Department of Endocrinology,Foshan Hospital of Traditional Chinese Medicine between January 2012 and June 2014,were included as the subjects in the study. The levels of plasma TGAb,TPOAb and TRAb antibodies in all patients were quantitatively determined. Results： The values and positive rates of plasma TGAb and TPOAb in patients with Hashimoto thyroiditis were the highest,which were1439. 0IU / ml,87. 7% and 427. 5IU / ml,97. 7%,respectively. The plasma TRAb value and positive rate were the highest in patients with Graves,which were 34. 44 IU / L and 100%,respectively. The plasma thyroid autoimmune antibodies in patients with simple goiter and subacute thyroiditis were increased in different degrees.There were statistically significant differences in TGAb,TPOAb and TRAb antibody levels among patients with four kinds of thyroid diseases in pairs（ P〈0. 05）,whereas no statistically significant difference was found in TRAb antibody level between patients with subacute thyroiditis and Hashimoto thyroiditis. Conclusion： There are differences in thyroid autoimmune antibodies TGAb,TPOAb and TRAb levels between different thyroid diseases.Combined analysis of the thyroid diseases,especially thyroid autoimmune disease,has significantly diagnostic value.
出处
《广州医科大学学报》
2015年第4期45-47,共3页
Academic Journal of Guangzhou Medical University
基金
佛山市卫生局医学科研立项课题(2013147)
