摘要
肝癌在中国的发病率较高,需要有效的治疗手段.近年来影像引导经皮射频消融(radiofrequency ablation,RFA)作为非手术治疗因其安全有效、对肝功能损伤小等优点已被广泛适用于治疗小肝癌,甚至可以与手术相媲美.然而,>3.0 cm的肿瘤往往易发生肿瘤残留复发而影响疗效.随着基础研究的开展和消融技术的进步,为RFA治疗较大肿瘤提供了更多机会.成功消融较大肝肿瘤的重要因素包括消融的技术设备、肿瘤的生物学特征及操作者手法经验等方面的结合.本文将根据这三个重要方面探讨较大肝肿瘤的治疗现状及前景.
The incidence of liver cancer is high in China and effective treatments are required.Recently,imaging guided radiofrequency ablation（RFA） has become increasingly accepted in treating solid tumors because of minimal invasiveness,easy operation and effectiveness.The outcome of RFA in small liver tumors is even comparable to that of surgery.However,the RFA efficacy in larger（ 3.0 cm） liver tumors is not satisfactory and recurrence after treatment is common.The development of basic research and RFA device has provided more opportunities for us to treat 3.0 cm liver tumors.The successful ablation of solid tumors relies on three key components,the technology（i.e.,the RFA generator and electrodes selected）,the biology of the tumor and background tissue,and operator factors.The current development and prospective of the three main elements will be the focus in this review.
出处
《世界华人消化杂志》
CAS
2015年第30期4771-4777,共7页
World Chinese Journal of Digestology
基金
国家自然科学基金面上基金资助项目
No.81471768
北京市卫生系统高层次卫生技术人才培养计划基金资助项目
No.2013-3-086~~
关键词
射频消融
肝癌
较大肿瘤
疗效
Radiofrequency ablation
Hepatocellular carcinoma
Medium to large tumor
Outcome
