摘要
目前眼部给药途径有眼表、结膜下、前房、巩膜、玻璃体腔给药和全身给药，人工晶状体（intraocular lens，IOL）是一个新型的潜在眼内载药系统。其优点为，药物直接曝露于前房，可以提高药物有效浓度；植入药物无需额外操作；IOL固定在囊袋或者睫状沟内也保证了药物位置的稳定性。目前将药物加载到IOL上的方法主要有浸泡吸附法、眼内植入剂法、等离子体接枝法、离子束注入法、化学交联接枝法、静电层层组装涂层法、高压静电喷涂法、超临界流体法等。IOL给药系统主要用于治疗眼内炎性反应和后发性白内障等白内障术后并发症。
Delivering drugs to the ocular system has many approaches including topical, subcon- junctival, intracameral, scleral, intravitreal, oral or intravenous administration. Intraocular lens （IOL） as an innovative drug reservoir has many advantages. Drug loading to IOL could work directly to the anterior chamber, providing higher intraocular drug concentration. It combines cataract surgery and postoperative treatments in a single procedure. Moreover IOL remains immobilized within the capsular bag or ciliary sulcus as a fixed drug releaser meanwhile. Nowadays several approaches undergone study to endow IOL with the a- bility of carrying different drugs are listed as followings： soaking, attaching a polymeric drug reservoir, plasma grafting, chemical grafting, layer-by-layer self-assembly deposition, coating, supercritical fluids impreg- nation and so on. IOL drug delivery systems are mainly designed to treat against the complications of cataract surgery such as endophthalmitis, inflammation reaction and posterior capsular opacification.
出处
《国际眼科纵览》
2015年第5期303-308,共6页
International Review of Ophthalmology
基金
国家自然科学基金（81100654）
关键词
人工晶状体
给药系统
表面修饰
intraocular lens
drug delivery system
surface modification
