摘要
目的:探讨普鲁卡因青霉素治疗二期梅毒临床效果,并观察和分析其及预后,为临床治疗提供依据。方法:选择本院2011年1月至2013年12月二期梅毒患者110例,随机分为对照组和观察组,对照组应用阿奇霉素治疗,观察组应用普鲁卡因青霉素治疗。观察各组患者治疗的临床治疗效果、皮疹消失时间,治疗后两年对患者进行随访,检测6、12、24个月的RPR转阴率和TRUST滴度。结果:观察组总有效为98.18%(54/55),高于对照组90.91%(50/55),差异有统计学意义(P<0.05);观察组皮疹消失时间为(10.39±1.06)d,低于对照组(13.50±1.17)d,差异有统计学意义(P<0.05);观察组第6个月RPR转阴率和TRUST滴度分别为30.91%(17/55)和1.53±0.54,对照组为21.82%(12/55)和(1.87±0.62),差异具有统计学意义(P<0.05)。结论:普鲁卡因青霉素和阿奇霉素治疗二期梅毒临床效果均较好,普鲁卡因青霉素更具优势,值得临床推广应用。
Objectives： To explore the clinical effect of procaine penicillin treatment for 2 - phase syphilis patients, and analyze its prognosis, so as to provide basis for clinical treatment. Methods： 110 2 -phase syphilis patients in our hospital from January 2011 to December 2013 were selected and randomly divided into the control group and the observation group. The control group reeeived azithromyein for treatment, and the observation group was given procaine penicillin for treatment. The clinical therapeutic effect and time for rash to disappear were ob- served. The RPR negative conversion ratio and the TRUST degree were detected 6, 12 and 24 months after the treat- ment. Results： The total effective rate of the observation grcup was 98.18% （54/55）, higher than the control group of 90. 91% （50/55）, with statistically significant difference （P 〈0. 05）. The time for rash to disappear in the observation group was （ 10. 39 ± 1.06） d, shorter than the control group of （ 13.50 ± 1.17） d, with statistically significant difference （ P 〈 0.05 ）. The RPR negative conversion ratio and the TRUST drops degree of the observa- tion group after 6 months were 30. 91% （17/55） and 1.53 ±0.54, and those in the control group were 21.82% （ 12/55 ） and 1.87 ± 0. 62, with statistically significant difference （ P 〈 0. 05 ）. Conclusion： Both procaine penicil- lin and azithromycin is effective in treating 2 - phrase syphilis, and procaine penicillin is of more advantages, which is worthy of clinical popularization and application.
出处
《中国性科学》
2015年第11期63-65,共3页
Chinese Journal of Human Sexuality
关键词
普鲁卡因青霉素
二期梅毒
临床效果
预后
Procaine penicillin
2 - phase syphilis
Cfinical effect
Prognosis
